Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease

Tetsuo Fujimaki; Kimihiko Kato; Tetsuro Yoshida; Mitsutoshi Oguri; Sachiro Watanabe; Norifumi Metoki; Hidemi Yoshida; Kei Satoh; Yukitoshi Aoyagi; Yutaka Nishigaki; Masashi Tanaka; Yoshinori Nozawa; Genjiro Kimura; Yoshiji Yamada

doi:10.1160/TH08-11-0761

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2009; 101(05): 963-968
DOI: 10.1160/TH08-11-0761

New Technologies, Diagnostic Tools and Drugs

Schattauer GmbH

Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease

Tetsuo Fujimaki

¹Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan

,

Kimihiko Kato

¹Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan

,

Tetsuro Yoshida

²Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan

,

Mitsutoshi Oguri

³Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

,

Sachiro Watanabe

⁴Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Japan

,

Norifumi Metoki

⁵Department of Internal Medicine, Hirosaki Stroke Center, Hirosaki, Japan

,

Hidemi Yoshida

⁶Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

,

Kei Satoh

⁶Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

,

Yukitoshi Aoyagi

⁷Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

,

Yutaka Nishigaki

⁷Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

,

Masashi Tanaka

⁷Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

,

Yoshinori Nozawa

⁸Gifu International Institute of Biotechnology, Kakamigahara, Japa

,

Genjiro Kimura

⁹Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

,

Yoshiji Yamada

¹⁰Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan

› Institutsangaben

Abstract

Summary

Chronic kidney disease (CKD) is a serious clinical condition that is associated with a high incidence of cardiovascular disease and end-stage renal disease. Although CKD has been recognised as a risk factor for myocardial infarction (MI), genetic factors for predisposition to MI in individuals with CKD have remained largely unknown. The purpose of the present study was to identify genetic variants that confer susceptibility to MI in Japanese individuals with CKD. The study subjects comprised 1,339 Japanese individuals with CKD, including 496 subjects with MI and 843 controls. The genotypes for 248 polymorphisms of 181 candidate genes were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. An initial screen of allele frequencies by the chi-square test revealed that the 11496G→A (Arg353Gln) polymorphism of F7 (rs6046) was significantly (false discovery rate <0.05) associated with the prevalence of MI in individuals with CKD. Subsequent multivariable logistic regression analysis with adjustment for covariates and a stepwise forward selection procedure also revealed that this polymorphism was significantly (p <0.005) associated with MI, with the variant A (Gln) allele protecting against this condition. Determination of genotype for the 11496G→A (Arg353Gln) polymorphism of F7 may prove informative for assessment of the genetic risk for MI in individuals with CKD.

Keywords

Chronic kidney disease - genetics - myocardial infarction - polymorphism

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Referenzen

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