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Thromb Haemost 2009; 102(05): 874-878
DOI: 10.1160/TH08-12-0797
DOI: 10.1160/TH08-12-0797
Theme Issue Article
The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
Weitere Informationen
Publikationsverlauf
Received:
08. Dezember 2008
Accepted after major revision:
01. Februar 2009
Publikationsdatum:
27. November 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200905/lookinside/thumbnails/10-1160-th08-12-0797-1.jpg)
Summary
The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.
Keywords
Circular dichroism - low-molecular-weight heparin - heparinoids - principal component analysis - quality control* Joint first authorship.
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