Thromb Haemost 2009; 102(02): 191-197
DOI: 10.1160/TH08-12-0844
Theme Issue Article
Schattauer GmbH

Novel aspects in the regulation of the leukocyte adhesion cascade

Emmanouil Chavakis
1   Institute of Cardiovascular Regeneration, Dept. of Internal Medicine III, J.W. Goethe University Frankfurt, Frankfurt, Germany
,
Eun Young Choi
2   Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland, USA
,
Triantafyllos Chavakis
2   Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland, USA
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 31. Dezember 2008

Accepted after minor revision: 10. Februar 2009

Publikationsdatum:
22. November 2017 (online)

Summary

Leukocyte recruitment plays a major role in the immune response to infectious pathogens and during inflammatory and autoimmune disorders. The process of leukocyte extravasation from the blood into the inflamed tissue requires a complex cascade of adhesive events between the leukocytes and the endothelium including leukocyte rolling, adhesion and transendothelial migration. Leukocyte-endothelial interactions are mediated by tightly regulated binding interactions between adhesion receptors on both cells. In this regard, leukocyte adhesion onto the endothelium is governed by leukocyte integrins and their endothelial counter-receptors of the immunoglobulin superfamily. The present review will focus on novel aspects with respect to the modulation of the leukocyte adhesion cascade.

 
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