Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications

Giovanni Tiscia; Donatella Colaizzo; Elena Chinni; Daniela Pisanelli; Natale Sciannamè; Giovanni Favuzzi; Maurizio Margaglione; Elvira Grandone

doi:10.1160/TH09-02-0123

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 102(02): 309-313
DOI: 10.1160/TH09-02-0123

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications

Giovanni Tiscia

¹Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

,

Donatella Colaizzo

¹Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

,

Elena Chinni

¹Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

,

Daniela Pisanelli

¹Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

,

Natale Sciannamè

²Obstetrics and Gynaecology, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

,

Giovanni Favuzzi

¹Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

,

Maurizio Margaglione

¹Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

³Medical Genetics, University of Foggia, Foggia, Italy

,

Elvira Grandone

¹Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), University of Foggia, Foggia, Italy

› Author Affiliations

Abstract

Summary

Inherited or acquired thrombophilias have been largely explored as a cause of pregnancy complications. However, pathogenesis of obstetric complications, as fetal loss and pregnancyrelated hypertensive disorders is still partly unexplained. Recently, a common haplotype (M2) within the annexin A5 (ANXA5) gene has been described as a risk factor in recurrent fetal losses (RFL). It has been demonstrated to reduce the promoter activity of the ANXA5 promoter in luciferase reporter assays. Aim of this study was to investigate the prevalence of M2 haplotype in three different settings of women with previous obstetric complications: RFL, intra-uterine fetal death (IUFD) and pregnancy-related hypertension (gestational hypertension [GH] and pre-eclampsia [PE]). One hundred three patients with previous RFL, 54 with IUFD, 158 with hypertensive disease (67 GH, 91 PE) were investigated. As controls,195 women from the same ethnic background with uneventful pregnancies were enrolled. Logistic regression, correcting for age, gravidity and parity showed that the ANXA5 haplotype is significantly and independently associated with the occurrence of RFL (3.1; 95%CI: 1.1–9.5; p=0.047) and pregnancy-related hypertensive disorders (2.1; 95%CI: 1.2–3.5; p=0.008).The M2 haplotype might be a new and relevant risk factor for obstetric complications.

Keywords

Annexins - pregnancy - polymorphism - risk factors

Full Text

References

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