Response to aspirin in healthy individuals

Normand Blais; Chantal Pharand; Marie Lordkipanidzé; Ying K. Sia; Yahye Merhi; Jean G. Diodati

doi:10.1160/TH09-02-0126

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2009; 102(02): 404-411
DOI: 10.1160/TH09-02-0126

New Technologies, Diagnostic Tools and Drugs

Schattauer GmbH

Response to aspirin in healthy individuals

Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B₂

Normand Blais

¹Hematology and blood bank department, CHUM, Hôpital Notre Dame, Montréal, Québec, Canada

³Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada

,

Chantal Pharand

²Faculty of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

⁴Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

⁵Department of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

,

Marie Lordkipanidzé

²Faculty of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

⁴Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

⁵Department of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

,

Ying K. Sia

⁴Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

,

Yahye Merhi

⁷Montreal Heart Institute Research Center, Montréal, Québec, Canada

,

Jean G. Diodati

³Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada

⁴Research Center, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

⁶Division of Cardiology, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

› Institutsangaben

Abstract

Summary

Variable biological effect of aspirin is suggested to be related to pharmacological resistance. The incidence of this so-called “resistant” state varies with the study population and the assay used. We determined performance features of five assays used to assess aspirin effects in non-smoking healthy volunteers not taking any drug known to interfere with platelet function. Blood and urine samples were obtained immediately before and after 8–10 days of aspirin 80 mg intake. Forty-five participants 19–59 years old were enrolled. The sensitivity (SE), specificity (SP), and optimal cut-off (CO) value to detect the effect of aspirin were: light transmission aggregometry (LTA) with 1.6 mM arachidonic acid (AA) – SE 100%,SP 95.9%,CO 20%;LTA with adenosine diphosphate (ADP) 10 µM – SE 84.4%, SP 77.8%, CO 70%; Ver-

Keywords

Agregometry - aspirin - thromboelastography - thromboxane - VerifyNow

Volltext

Referenzen

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