Clot formation of neonates tested by thromboelastography correlates with gestational age

Tzipi Strauss; Yael Levy-Shraga; Bruria Ravid; Irit Schushan-Eisen; Ayala Maayan-Metzger; Jacob Kuint; Gili Kenet

doi:10.1160/TH09-05-0282

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 103(02): 344-350
DOI: 10.1160/TH09-05-0282

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Clot formation of neonates tested by thromboelastography correlates with gestational age

Tzipi Strauss

¹Neonatolgy, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

³Thrombosis Unit, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

,

Yael Levy-Shraga

²Pediatric Hematoloy, Safra Medical Center for Children, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

,

Bruria Ravid

³Thrombosis Unit, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

,

Irit Schushan-Eisen

¹Neonatolgy, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

,

Ayala Maayan-Metzger

¹Neonatolgy, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

,

Jacob Kuint

¹Neonatolgy, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

,

Gili Kenet

³Thrombosis Unit, National Hemophilia Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel

› Author Affiliations

Abstract

Summary

Evaluation of clot formation in neonates is troublesome. Our aim was to investigate cord blood clot formation of pre-term versus full-term infants and adults, using rotating thromboelastogram (ROTEM^®, Pentafarm, Munich, Germany). ROTEM was investigated in cord blood of 184 full-term and 47 pre-term infants. Measurements of the clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) were obtained in order to asses reference values for this age group, and compare between full-term and pre-term neonates and compared to adult controls. For each infant demographic information and data regarding pregnancy and delivery were gathered. Infants were prospectively followed until discharge. CT and CFT were significantly shorter among pre-term and term infants as compared to adults [median CT: 185, 194, 293 seconds respectively, p≤0.001, CFT: 80, 76, 103 seconds respectively, p≤0.001). MCF was lower in pre-term and term as compared to adults (p≤0.001) with significantly lower values in pre-term as compared to full-term neonates (p=0.004). Clotting time and MCF correlated with gestational age (R=0.132, p=0.045, R= 0.259, p<0.001, respectively). No association was found between any ROTEM values and the occurrence of post-natal complications in infants of our study group. This is the first study assessing clot formation by ROTEM in pre-term infants. Clot formation parameters of term and premature infants correlated with gestational age. The predictive value of clot formation tests in neonates deserves further attention.

Keywords

Neonates - preterm - coagulation - thromboelastography - ROTEM

Full Text

References

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