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Thromb Haemost 2009; 102(06): 1103-1109
DOI: 10.1160/TH09-05-0323
Theme Issue Article
Schattauer GmbH

Role of Toll-like receptors, NOD-like receptors and RIG-I-like receptors in endothelial cells and systemic infections

Bastian Opitz
1   Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
,
Julia Eitel
1   Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
,
Karolin Meixenberger
1   Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
,
Norbert Suttorp
1   Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
› Author AffiliationsFinancial support: B.O. is supported by grants given by the Deutsche Forschungsgemeinschaft (OP 86/5-1, OP 86/7-1) and by the Jürgen Manchot Foundation.
Further Information

Publication History

Received: 22 May 2009

Accepted: 30 September 2009

Publication Date:
28 November 2017 (online)

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Summary

Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by producing inflammatory mediators and expressing surface molecules. The initial sensing of microbial and endogenous danger-associated molecules is mediated by so-called pattern recognition receptors (PRRs). PRRs can be classified in different protein families such as the Toll-like receptors, the NODlike receptors and the RIG-I-like receptors. By activating inflammatory gene transcription and posttranslational processing, PRRs control the immediate innate immune reaction and also the subsequent adaptive immune response. Here we describe the current knowledge of extra-and intracellular PRRs in endothelial cells and their potential role in sepsis and vascular diseases.

Keywords

Toll-like receptor - NOD-like receptors - RIG-I-like receptor - endothelial cells
 

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