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Thromb Haemost 2009; 102(06): 1117-1134
DOI: 10.1160/TH09-07-0472
DOI: 10.1160/TH09-07-0472
Theme Issue Article
The contribution of systems biology and reverse genetics to the understanding of Kaposi’s sarcoma-associated herpesvirus pathogenesis in endothelial cells
Financial support: This work was supported by grants of the Deutsche Forschungsgemeinschaft (DFG-SPP 1130 to MS and TFS; DFG-SFB 566 to TFS; DFG-GK 1071 and DFG 317/2-1 to MS), the Interdisciplinary Center for Clinical Research (IZKF) of the University of Erlangen-Nuremberg (to M.S) and the European Union (FP6 Integrated project INCALSHC- CT-2005-018704 to TFS).Weitere Informationen
Publikationsverlauf
Received:
22. Juli 2009
Accepted after minor revision:
05. November 2009
Publikationsdatum:
28. November 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200906/lookinside/thumbnails/10-1160-th09-07-0472-1.jpg)
Summary
Kaposi’s sarcoma-associated herpesvirus (KSHV) / human herpesvirus-8 is the causative agent of the endothelial cell-derived tumour Kaposi’s sarcoma. Herpesviruses possess large complex genomes which provide many options to regulate cellular physiology during the viral life cycle and in the course of tumourigenicity. Novel techniques of systems biology and reverse genetics are increasingly applied to dissect the complex interaction of KSHV with endothelial cells. This review will outline novel results and pitfalls of these technologies in the elucidation of KSHV pathogenicity.
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