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Thromb Haemost 2010; 103(01): 56-61
DOI: 10.1160/TH09-08-0562
Review Article
Schattauer GmbH

Endothelium, venous thromboembolism and ischaemic cardiovascular events

Paolo Gresele
1   Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
,
Stefania Momi
1   Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
,
Rino Migliacci
2   Division of Internal Medicine, Ospedale della Valdichiana “S.Margherita”, Cortona, Italy
› Author Affiliations
Further Information

Publication History

Received: 14 August 2009

Accepted after minor revision: 25 September 2009

Publication Date:
22 November 2017 (online)

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Summary

The association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of experimental and clinical observations suggesting that the common link between venous thromboembolism and arterial thrombosis is represented by a dysfunctional endothelium.

Keywords

Arterial thrombosis - atherothrombosis - venous thrombosis - endothelial cells - nitric oxide/NO
 

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