Tissue factor and thrombosis: The clot starts here

A. Phillip Owens III; Nigel Mackman

doi:10.1160/TH09-11-0771

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 104(03): 432-439
DOI: 10.1160/TH09-11-0771

Theme Issue Article

Schattauer GmbH

Tissue factor and thrombosis: The clot starts here

A. Phillip Owens III

¹Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

,

Nigel Mackman

¹Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

› Author Affiliations

Abstract

Summary

Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary to better understand the complex components and interactions involved in the formation of a clot. Tissue factor (TF) is required for the initiation of blood coagulation and likely plays a key role in both arterial and venous thrombosis. Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis.

Keywords

Tissue factor / factor VII - thrombosis - arterial thrombosis - venous thrombosis - animal models

Full Text

References

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