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Thromb Haemost 2010; 104(03): 464-470
DOI: 10.1160/TH09-12-0814
Theme Issue Article
Schattauer GmbH

Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1

Wei Ling Lau
1   Nephrology, University of Washington, Seattle, Washington, USA
,
Maria H. Festing
2   Bioengineering, University of Washington, Seattle, Washington, USA
,
Cecilia M. Giachelli
2   Bioengineering, University of Washington, Seattle, Washington, USA
› Institutsangaben Financial support:Dr. Giachelli’s research is supported by NIH grants HL62329, HL081785, and HL18645. W.L. Lau is funded by DK007467, and M.H. Festing is funded by NIH HL07828.
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Publikationsverlauf

Received: 02. Dezember 2009

Accepted after major revision: 01. Juli 2010

Publikationsdatum:
23. November 2017 (online)

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Summary

Elevated serum phosphate is a risk factor for vascular calcification and cardiovascular events in kidney disease as well as in the general population. Elevated phosphate levels drive vascular calcification, in part, by regulating vascular smooth muscle cell (VSMC) gene expression, function, and fate. The type III sodium-dependent phosphate co-transporter, PiT-1, is necessary for phosphate-induced VSMC osteochondrogenic phenotype change and calcification, and has recently been shown to have unexpected functions in cell proliferation and embryonic development.

Keywords

Phosphate - vascular calcification - PiT-1 - kidney disease
 

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