The effect of ethanol and its metabolism on fibrinolysis

Marlien Pieters; Hester H. Vorster; Johann C. Jerling; Christine S. Venter; Retha C. M. Kotze; Elsabe Bornman; Joyce J. M. C. Malfliet; Dingeman C. Rijken

doi:10.1160/TH10-01-0048

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2010; 104(04): 724-733
DOI: 10.1160/TH10-01-0048

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

The effect of ethanol and its metabolism on fibrinolysis

Marlien Pieters

¹TReNDS Centre of Excellence – Nutrition, North-West University, Potchefstroom, South Africa

,

Hester H. Vorster

¹TReNDS Centre of Excellence – Nutrition, North-West University, Potchefstroom, South Africa

,

Johann C. Jerling

¹TReNDS Centre of Excellence – Nutrition, North-West University, Potchefstroom, South Africa

,

Christine S. Venter

¹TReNDS Centre of Excellence – Nutrition, North-West University, Potchefstroom, South Africa

,

Retha C. M. Kotze

¹TReNDS Centre of Excellence – Nutrition, North-West University, Potchefstroom, South Africa

,

Elsabe Bornman

²School of Nursing Science, North-West University, Potchefstroom, South Africa

,

Joyce J. M. C. Malfliet

³Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands

,

Dingeman C. Rijken

³Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands

› Institutsangaben

Abstract

Summary

The role of ethanol metabolism in possible haemostatic cardioprotective effects has not yet been determined. To this end, we investigated the effect of a moderate dose of ethanol (35 g) and its metabolism, on haemostatic variables over 14 hours (h). Eighteen Caucasian males participated in a placebo-controlled, randomised, cross-over study. Blood was collected prior to alcohol consumption, and at 10 time points for 14 h. Blood ethanol peaked at 1 h and was cleared after 8 h following ethanol consumption, significantly increasing plasma acetate (p=0.0028). Ethanol did not influence the coagulation factors significantly. PAI-1_act increased (p<0.0001) and tPA_act (p=0.047) decreased following alcohol consumption, reaching maximum (0.69 to 22.2 IU/ml) and minimum (0.88 to 0.33 IU/ml) levels at 5 h, respectively. Significantly increased plasma clot lysis times (46.8 to 67.6 minutes) and reduced global fibrinolytic capacity of whole blood, measured as D-dimer production during incubation of blood clots (2.26 to 0.29 μg/ml), were found at 5 h. Except for PAI-1_act (borderline significance; p=0.05), there was no significant difference in the fibrinolytic markers between the two groups the following morning. Moderate ethanol consumption resulted in a significant temporary fibrinolysis inhibition. Any protective effects of moderate ethanol consumption on cardiovascular disease do not appear to be due to improvement in fibrinolytic potential within the first 14 h following consumption. The use of global fibrinolytic assays is recommended for determining the true effect of ethanol on fibrinolysis.

Keywords

Acetate - alcohol - fibrinolysis - PAI-1_act - tPA_act

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Referenzen

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