Circulating monocyte subsets and cardio - vascular risk factors in coronary artery disease

Mihail Hristov; Thorsten Leyendecker; Christoph Schuhmann; Philipp von Hundels-hausen; Nicole Heussen; Eva Kehmeier; Florian Krötz; Hae-Young Sohn; Volker Klauss; Christian Weber

doi:10.1160/TH10-01-0069

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 104(02): 412-414
DOI: 10.1160/TH10-01-0069

Letters to the Editor

Schattauer GmbH

Circulating monocyte subsets and cardio - vascular risk factors in coronary artery disease

Authors

Mihail Hristov

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany
Thorsten Leyendecker^*

²Department of Cardiology, RWTH Aachen University, Aachen, Germany
Christoph Schuhmann

⁴Department of Cardiology, Ludwig-Maximilians-University Munich, Munich, Germany
Philipp von Hundels-hausen

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

²Department of Cardiology, RWTH Aachen University, Aachen, Germany
Nicole Heussen

³Institute for Medical Statistics, RWTH Aachen University, Aachen, Germany
Eva Kehmeier^*

²Department of Cardiology, RWTH Aachen University, Aachen, Germany
Florian Krötz

⁴Department of Cardiology, Ludwig-Maximilians-University Munich, Munich, Germany
Hae-Young Sohn

⁴Department of Cardiology, Ludwig-Maximilians-University Munich, Munich, Germany
Volker Klauss

⁴Department of Cardiology, Ludwig-Maximilians-University Munich, Munich, Germany
Christian Weber

¹Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

Abstract

Full Text

References

References
1 Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 2008; 08: 802-815.
2 Ziegler-Heitbrock L. The CD14+CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 2007; 81: 584-592.
3 Weber C, Belge KU, von Hundelshausen P. et al. Differential chemokine receptor expression and funcion in human monocyte subpopulations. J Leukoc Biol 2000; 67: 699-704.
4 Shantsila E, Lip GY. Monocyte diversity in myocardial infarction. J Am Coll Cardiol 2009; 54: 139-142.
5 Ancuta P, Rao R, Moses A. et al. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med 2003; 197: 1701-1707.
6 Draude G, von Hundelshausen P, Frankenberger M. et al. Distinct scavenger receptor expression and function in the human CD14(+)/CD16(+) monocyte subset. Am J Physiol 1999; 276: H1144-1149.
7 Schlitt A, Heine GH, Blankenberg S. et al. CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost 2004; 92: 419-424.
8 Murdoch C, Tazzyman S, Webster S. et al. Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol 2007; 178: 7405-7411.
9 Venneri MA, De Palma M, Ponzoni M. et al. Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 2007; 109: 5276-5285.
10 De Palma M, Murdoch C, Venneri MA. et al. Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications. Trends Immunol 2007; 28: 519-524.
11 Tsujioka H, Imanishi T, Ikejima H. et al. Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. J Am Coll Cardiol 2009; 54: 130-138.
12 Heine GH, Ulrich C, Seibert E. et al. CD14(++)CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients. Kidney Int 2008; 73: 622-629.
13 Hristov M, Schmitz S, Schuhmann C. et al. An optimized flow cytometry protocol for analysis of angiogenic monocytes and endothelial progenitor cells in peripheral blood. Cytometry A 2009; 75: 848-853.
14 Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352: 1685-95.
15 Mosig S, Rennert K, Krause S. et al. Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14+ CD16+ monocytes in detoxification of oxidized LDL. FASEB J 2009; 23: 866-874.
16 Madjid M, Awan I, Willerson JT. et al. Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol 2004; 44: 1945-1956.
17 Rothe G, Gabriel H, Kovacs E. et al. Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia. Arterioscler Thromb Vasc Biol 1996; 16: 1437-1447.
18 Timmerman KL, Flynn MG, Coen PM. et al. Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?. J Leukoc Biol 2008; 84: 1271-1278.
19 Rogacev KS, Ulrich C, Blömer L. et al. Monocyte heterogeneity in obesity and subclinical atherosclerosis. Eur Heart J 2010; 31: 369-376.

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