CYP1A1, smoking and venous thromboembolism

Jin Zhu; Wen-Jie Zheng; Fan-Cui Kong; Wei-Juan Zhang; He-Yao Wang; Chen Wang

doi:10.1160/TH10-01-0078

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 104(04): 702-708
DOI: 10.1160/TH10-01-0078

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

CYP1A1, smoking and venous thromboembolism

Jin Zhu^*

¹Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University, Beijing, China

,

Wen-Jie Zheng^*

²School of Life Science & Technology, Beijing Institute of Technology, Beijing, China

,

Fan-Cui Kong

¹Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University, Beijing, China

,

Wei-Juan Zhang

¹Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University, Beijing, China

,

He-Yao Wang

¹Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University, Beijing, China

,

Chen Wang

¹Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University, Beijing, China

› Author Affiliations

Abstract

Summary

Since CYP1A1 enzyme is involved in metabolism of tobacco carcinogens, the CYP1A1 gene may be of relevance to smoking-induced differences in the risks of venous thromboembolism (VTE). We conducted a case-control study to investigate genetic polymorphisms in CYP1A1 that might modify the risk of developing VTE. A total of 425 Chinese patients with VTE and 527 VTE-free control individuals, matched by age and gender, were included in this analysis. The MspI and Ile462Val polymorphisms in CYP1A1 gene were analysed using the Amplification Refractory Mutation System (ARMS) method. The Ile462Val AG variant and combined AG and GG variant was significantly associated with VTE, adjusted for age, gender, weight and contraceptives (OR=1.362, 95%CI 1.026, 1.809, p=0.033; OR=1.420, 95% CI 1.081, 1.865, p=0.012, respectively); The AG and GG combined variant was still significantly associated with VTE when adjusting further for smoking (OR=1.344, 95%CI 1.019,1.772, p=0.036) A more than two-fold increase for VTE was associated with the Ile462Val combined variant of AG+GG (OR of 2.805, 95% CI 1.250, 6.293, p=0.012) in the smokers. Genetic variations of CYP1A1 Ile462Val contribute to susceptibility to smoking-induced VTE in the Chinese populations. A two-fold increase in the risk in the smokers in the patients who carry CYP1A1 Ile462Val variant alleles has demonstrated the importance of gene-environment interactions in the development of this disease.

Keywords

CYP1A1 - smoking - venous thromboembolism - ARMS - Chinese

Full Text

References

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