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Thromb Haemost 2010; 104(01): 39-44
DOI: 10.1160/TH10-05-0269
DOI: 10.1160/TH10-05-0269
Theme Issue Article
Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases
Further Information
Publication History
Received:
13 May 2010
Accepted after minor revision:
26 May 2010
Publication Date:
23 November 2017 (online)
Summary
Recent advances in stem cell biology have transformed the understanding of cell physiology and developmental biology such that it can now play a more prominent role in the clinical application of stem cell and regenerative medicine. Success in the generation of human induced pluripotent stem cells (iPS) as well as related emerging technology on the iPS platform provide great promise in the development of regenerative medicine. Human iPS cells show almost identical properties to human embryonic stem cells (ESC) in pluripotency, but avoid many of their limitations of use. In addition, investigations into reprogramming of somatic cells to pluripotent stem cells facilitate a deeper understanding of human stem cell biology. The iPS cell technology has offered a unique platform for studying the pathogenesis of human disease, pharmacological and toxicological testing, and cell-based therapy. Nevertheless, significant challenges remain to be overcome before the promise of human iPS cell technology can be realised.
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