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Thromb Haemost 2011; 105(01): 81-87
DOI: 10.1160/TH10-05-0316
Platelets and Blood Cells
Schattauer GmbH

Effects of Aggrenox and aspirin on plasma endothelial nitric oxide synthase and oxidised low-density lipoproteins in patients after ischaemic stroke

The AGgrenox versus Aspirin Therapy Evaluation (AGATE) Biomarker Substudy
Victor Serebruany
1   Johns Hopkins University; Baltimore, Maryland, USA
,
Yanti Sani
2   Sarawak General Hospital, Kuching, Malaysia
,
Christian Eisert
3   University of Michigan, Ann Arbor, Michigan, USA
,
Alex Schevchuck
4   University of New Mexico, Albuquerque, New Mexico, USA
,
Alan Fong
2   Sarawak General Hospital, Kuching, Malaysia
,
Dan Hanley
1   Johns Hopkins University; Baltimore, Maryland, USA
› Author Affiliations Financial support: The study was supported in part by Boehringer Ingelheim, (Ingelheim am Rhein, Germany).
Further Information

Publication History

Received: 24 May 2010

Accepted after major revision: 08 September 2010

Publication Date:
22 November 2017 (online)

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Summary

Plasma endothelial nitric oxide synthase (eNOS), and oxidised low-density lipoproteins (oxLDL) are established biomarkers of atherosclerosis. We defined the time course and magnitude of changes of plasma eNOS and oxLDL after Aggrenox or aspirin in post-stroke patients. Baseline pretreatment eNOS levels were significantly diminished (110 ± 66pg /ml vs. 374 ± 88 pg/ml, p=0.0001), while oxLDL was twice higher (58 ± 9 mg/l vs. 23 ± 7 mg/l, p=0.004) in post-stroke survivors when compared to controls. Both Aggrenox and aspirin similarly increased plasma eNOS activity. However, oxLDL levels were static after aspirin, but inhibited late after Aggrenox. In the small randomised study, both aspirin and Aggrenox produced fast and sustained recovery of plasma eNOS levels, while only therapy with Aggrenox was associated with oxLDL inhibition late in the trial.

Keywords

Stroke - aspirin - Aggrenox - nitric oxide - oxidised LDL
 

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