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Thromb Haemost 2011; 105(04): 735-736
DOI: 10.1160/TH10-11-0718
Letters to the Editor
Schattauer GmbH

Measuring the anticoagulant effect of direct factor Xa inhibitors. Is the anti-Xa assay preferable to the prothrombin time test?

Armando Tripodi
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore Policlinico Ca’ Granda Foundation and Università degli Studi di Milano, Milano, Italy
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Publication History

Received: 11 November 2010

Accepted after mainor revision: 24 January 2010

Publication Date:
28 November 2017 (online)

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  • References

  • 1 Barrett YC, Wang Z, Frost C. et al. Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb Haemost 2010; 104: 1263-1271.
    Thieme ConnectPubMedSearch in Google Scholar
  • 2 van den Besselaar AMHP, Poller L, Tripodi A. Guidelines for thromboplastins and plasmas used to control oral anticoagulant therapy (1999). WHO Technical Report Series 1999; 889: 64-93.
    PubMedSearch in Google Scholar
  • 3 Tripodi A, Chantarangkul V, Primignani M. et al. The international normalized ratio calibrated for cirrhosis (INRliver) normalizes prothrombin time results for model for end-stage liver disease calculation. Hepatology 2007; 46: 520-527.
    CrossrefPubMedSearch in Google Scholar
  • 4 Tripodi A, Chantarangkul V, Primignani M. et al. Point-of-Care Coagulation Monitors Calibrated for the International Normalized Ratio for Cirrhosis (INRliver) Can Help to Implement the INRliver for the Calculation of the MELD Score. J Hepatol 2009; 51: 288-295.
    CrossrefPubMedSearch in Google Scholar
  • 5 Tripodi A, Baglin T, Robert A. et al, on behalf of the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. Reporting Prothrombin Time Results as International Normalised Ratios for Patients with Chronic Liver Disease. J Thromb Haemost 2010; 8: 1410-1412.
    CrossrefPubMedSearch in Google Scholar
  • 6 Bellest L, Eschwege V, Poupon R. et al. A modified international normalized ratio as an effective way of prothrombin time standardization in hepatology. Hepatology 2007; 46: 528-534.
    CrossrefPubMedSearch in Google Scholar
  • 7 Sermon AM, Smith JM, Maclean R. et al. An International Sensitivity Index (ISI) derived from patients with abnormal liver function improves agreement between INRs determined with different reagents. Thromb Haemost 2010; 103: 757-765.
    Thieme ConnectPubMedSearch in Google Scholar
  • 8 Kim HK, Hong KH, Toh CH. On behalf of the Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis (ISTH). Application of the International Normalized Ratio (INR) in the Scoring System for Disseminated Intravascular Coagulation (DIC). J Thromb Haemost 2010; 8: 1116-1118.
    PubMedSearch in Google Scholar
  • 9 Tripodi A, Chantarangkul V, Guinet C. et al. The INR Calibrated for Rivaroxaban-(INRrivaroxaban) has the Potential to Normalize PT Results for Rivaroxaban-treated Patients. Results of an in-vitro Study. J Thromb Haemost. 2010 prepublished online doi:10.1111/j.1538–7836.2010.04106.x.
    PubMedSearch in Google Scholar