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Thromb Haemost 2011; 106(01): 182-184
DOI: 10.1160/TH11-01-0051
Letters to the Editor
Schattauer GmbH

Is increased platelet turnover responsible for low responsiveness to different thienopyridienes? A case report of recurrent stent thromboses

Matthias K. Freynhofer   *
1   3rd Medical Department, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna, Austria
,
Veronika Bruno   *
2   Department of Obstetrics and Gynecology, Wilhelminenhospital, Vienna, Austria
,
Ivan Brozovic
1   3rd Medical Department, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna, Austria
,
Erik L. Grove
3   Department of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark
,
Steen D. Kristensen
3   Department of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark
,
Martin Willheim
4   Department of Laboratory Medicine, Wilhelminenhospital, Vienna, Austria
,
Wolfgang Hübl
4   Department of Laboratory Medicine, Wilhelminenhospital, Vienna, Austria
,
Kurt Huber
1   3rd Medical Department, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna, Austria
› Author Affiliations Financial support: This work was supported by the Austrian Society of Cardiology, the Association for the Promotion of Research in Arteriosclerosis, Thrombosis and Vascular Biology and by the Ludwig Boltzmann Foundation for Cardiovascular Research.
Further Information

Publication History

Received: 31 January 2011

Accepted after major revision: 14 March 2011

Publication Date:
24 November 2017 (online)

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* M. K. Freynhofer and V. Bruno contributed equally to this case report (shared first authorship).


 

  • References

  • 1 Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Br Med J 2002; 324: 71-86.
    CrossrefPubMedGoogle Scholar
  • 2 Siller-Matula J, Schror K, Wojta J. et al. Thienopyri- dines in cardiovascular disease: focus on clopidogrel resistance. Thromb Haemost 2007; 97: 385-393.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Sofi F, Marcucci R, Gori AM. et al. Clopidogrel nonresponsiveness and risk of cardiovascular morbidity. An updated meta-analysis. Thromb Haemost 2010; 103: 841-848.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Grove EL, Kristensen SD. Update on oral antiplatelet therapy: principles, problems and promises. Future Cardiol 2009; 5: 247-258.
    CrossrefPubMedGoogle Scholar
  • 5 Murphy SA, Antman E. M, Wiviott S. D, Weerakkody G, Morocutti G, Huber K, Lopez-Sendon J, McCabe C. H, Braunwald E.. Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial. Eur Heart J 2008; 29: 2473-2479.
    CrossrefPubMedGoogle Scholar
  • 6 Jakubowski JA, Payne CD, Li YG. et al. A comparison of the antiplatelet effects of prasugrel and highdose clopidogrel as assessed by VASP-phosphory- lation and light transmission aggregometry. Thromb Haemost 2008; 99: 215-222.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Angiolillo DJ, Saucedo JF, Deraad R. et al. Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWAP (Switching Anti Platelet) study. J Am Coll Cardiol 2010; 56: 1017-1023.
    CrossrefPubMedGoogle Scholar
  • 8 Guthikonda S, Alviar CL, Vaduganathan M. et al. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease. J Am Coll Cardiol 2008; 52: 743-749.
    CrossrefPubMedGoogle Scholar
  • 9 Hirsh J, Glynn MF, Mustard JF. The effect of platelet age on platelet adherence to collagen. J Clin Invest 1968; 47: 466-473.
    CrossrefPubMedGoogle Scholar
  • 10 Jakubowski JA, Thompson CB, Vaillancourt R. et al. Arachidonic acid metabolism by platelets of differing size. Br J Haematol 1983; 53: 503-511.
    CrossrefPubMedGoogle Scholar
  • 11 Briggs C, Kunka S, Hart D. et al. Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. Br J Haematol 2004; 126: 93-99.
    CrossrefPubMedGoogle Scholar
  • 12 Grove EL, Hvas AM, Kristensen SD. Immature platelets in patients with acute coronary syndromes. Thromb Haemost 2009; 101: 151-156.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Gonzalez-Porras JR, Martin-Herrero F, Gonzalez-Lopez TJ. et al. The role of immature platelet fraction in acute coronary syndrome. Thromb Haemost 2010; 103: 247-249.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Wurtz M, Grove EL, Wulff LN. et al. Patients with previous definite stent thrombosis have a reduced antiplatelet effect of aspirin and a larger fraction of immature platelets. JACC Cardiovasc Interv 2010; 3: 828-835.
    CrossrefPubMedGoogle Scholar
  • 15 Cutlip DE, Windecker S, Mehran R. et al. Clinical end points in coronary stent trials: a case for standardized definitions. Circulation 2007; 115: 2344-2351.
    CrossrefPubMedGoogle Scholar
  • 16 Brar SS, Leon MB, Stone GW. et al. Use of drug-eluting stents in acute myocardial infarction: a systematic review and meta-analysis. J Am Coll Cardiol 2009; 53: 1677-1689.
    CrossrefPubMedGoogle Scholar
  • 17 Wijns W, Kolh P, Danchin N. et al. Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2010; 31: 2501-2555.
    CrossrefPubMedGoogle Scholar
  • 18 Aleil B, Jacquemin L, De Poli F. et al. Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study. JACC Cardiovasc Interv 2008; 1: 631-638.
    CrossrefPubMedGoogle Scholar
  • 19 Mehta SR, Tanguay JF, Eikelboom JW. et al. Doubledose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet 2010; 376: 1233-1243.
    CrossrefPubMedGoogle Scholar
  • 20 Montalescot G, Sideris G, Cohen R. et al. Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study. Thromb Haemost 2010; 103: 213-223.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 21 Bonello L, Tantry US, Marcucci R. et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol 2010; 56: 919-933.
    CrossrefPubMedGoogle Scholar
  • 22 Sibbing D, Morath T, Braun S. et al. Clopidogrel response status assessed with Multiplate point-of-care analysis and the incidence and timing of stent thrombosis over six months following coronary stenting. Thromb Haemost 2010; 103: 151-159.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 23 Kuliczkowski WA, Polonski L, Watala C. et al. Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J 2009; 30: 426-435.
    PubMedGoogle Scholar
  • 24 Hochtl T, Pachinger L, Unger G. et al. Antiplatelet drug induced isolated profound thrombocytopenia in interventional cardiology: a review based on individual case reports. J Thromb Thrombolysis 2007; 24: 59-64.
    CrossrefPubMedGoogle Scholar
  • 25 De Caterina R, Zimarino M. Understanding the complexity of abciximab-related thrombocytopenia. Thromb Haemost 2010; 103: 484-486.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 De Labriolle A, Bonello L, Lemesle G. et al. Decline in platelet count in patients treated by percutaneous coronary intervention: definition, incidence, prognostic importance, and predictive factors. Eur Heart J 2010; 31: 1079-1087.
    CrossrefPubMedGoogle Scholar
  • 27 Grove EL, Hvas AM, Mortensen SB. et al. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Haemost 2011; 9: 185-191.
    CrossrefPubMedGoogle Scholar