Short-term effects of the smoke-free legislation on haemostasis and systemic inflammation due to second hand smoke exposure

Guillaume Cayla; Pierre Sie; Johanne Silvain; Delphine Brugier; Jean-Pierre Cambou; Daniel Thomas; Ana Pena; Stephen A. O’Connor; Alessandra Bura; Jean-Bernard Ruidavets; Gilles Montalescot; Jean-Philippe Collet

doi:10.1160/TH11-02-0062

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2011; 105(06): 1024-1031
DOI: 10.1160/TH11-02-0062

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Short-term effects of the smoke-free legislation on haemostasis and systemic inflammation due to second hand smoke exposure

The AERER^[*] study

Guillaume Cayla

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

,

Pierre Sie

²Toulouse Laboratory of Haematology, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC) INSERM 1048, CHU de Toulouse and Université Paul Sabatier, Toulouse, France

,

Johanne Silvain

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

,

Delphine Brugier

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

,

Jean-Pierre Cambou

³University of Toulouse, Rangueil University Hospital, Dept. of Vascular Medicine, Toulouse, France

,

Daniel Thomas

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

,

Ana Pena

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

,

Stephen A. O’Connor

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

,

Alessandra Bura

³University of Toulouse, Rangueil University Hospital, Dept. of Vascular Medicine, Toulouse, France

,

Jean-Bernard Ruidavets

⁴Department of Epidemiology, Health Economics and Public Health, UMR 558 INSERM, Université de Toulouse, CHU de Toulouse, Toulouse, France

,

Gilles Montalescot

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

,

Jean-Philippe Collet

¹Institut de Cardiologie, INSERM_UMR_937, Pitié-Salpêtrière University Hospital (AP-HP), Université Paris 6, Paris, France

› Institutsangaben

Abstract

Summary

It was the objective of this study to assess the effect of the implementation of the smoke-free legislation on haemostasis and systemic inflammation in second-hand smoking (SHS)-exposed healthy volunteers. Fibrin-rich clot properties, platelet reactivity and inflammatory biomarkers were measured before and four months following the implementation of the smoke-free legislation in gender and age-matched healthy volunteers exposed (n=23, exposed) and unexposed (n=23, controls) to occupational SHS. The primary objective was to compare fibrin-rich clot stiffness before and after implementation of the smoke-free legislation. There was 40% reduction in fibrin-rich clot stiffness following the implementation of the smoke-free legislation in SHS-exposed volunteers (17 ± 7 vs. 10.6 ± 7 dynes/cm², before and after, respectively, p=0.001). These dramatic changes were associated with a 20% reduction in fibrin fiber density (p<0.01) and a 20% reduction inclot lysis time (p=0.05). No change in fibrin properties was observed in the control group of SHS-unexposed volunteers related to the implementation of the smoke-free legislation. Of interest, neither platelet reactivity nor systemic inflammatory biomarkers were changed in either group. The smoke-free legislation is associated with significant changes in fibrin-rich clot properties toward a less thrombogenic conformation with a better fibrinolysis response while neither platelet reactivity nor systemic inflammatory biomarkers are modified. These improvements may explain the observed reduction in acute coronary syndrome following the implementation of the smoke-free legislation.

Keywords

Second hand smoke - smoke-free legislation - fibrin-clot - platelet reactivity - inflammatory biomarkers

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