Deep-vein thrombosis: A United States cost model for a preventable and costly adverse event

Charles E. Mahan; Mark T. Holdsworth; Shawn M. Welch; Matt Borrego; Alex C. Spyropoulos

doi:10.1160/TH11-02-0132

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2011; 106(03): 405-415
DOI: 10.1160/TH11-02-0132

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Deep-vein thrombosis: A United States cost model for a preventable and costly adverse event

Authors

Charles E. Mahan

¹University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA
Mark T. Holdsworth

¹University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA
Shawn M. Welch

²Cardinal Health Pharmacy Solutions, Lovelace Medical Center, Albuquerque, New Mexico, USA
Matt Borrego

¹University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA
Alex C. Spyropoulos

³Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Abstract

Summary

Preventable venous thromboembolism (VTE) and “appropriate” type, dose, and duration of prophylaxis are emerging concepts. Contemporary definitions by key quality organisations, including the World Health Organization, have shifted towards “preventable” VTE being considered an adverse event or adverse drug event. A decision tree and cost model were developed to estimate the United States health care costs for total deep-vein thrombosis (DVT), total hospital-acquired DVT, and total “preventable” DVT. Annual cost ranges were obtained in 2010 US dollars for total ($7.5 to $39.5 billion), hospital-acquired ($5 to $26.5billion), and preventable ($2.5 to $19.5 billion) DVT costs. When the sensitivity analysis was applied – taking into consideration higher incidence rates and costs – annual US total, hospital-acquired, and “preventable” DVT costs ranged from $9.8 to $52 billion, $6.8 to $36 billion, and $3.4 to $27 billion, respectively.

keywords

Adverse drug event - adverse event - cost model - deep-vein thrombosis - preventable

Full Text

References

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