Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus

Marie-Christine Alessi; Viviane Nicaud; Ilse Scroyen; Celine Lange; Noemie Saut; Frederic Fumeron; Michel Marre; Olivier Lantieri; Benedicte Fontaine-Bisson; Iréne Juhan-Vague; Beverley Balkau; David-Alexandre Tregouet; Pierre-Emmanuel Morange; D.E.S.I.R. Study Group

doi:10.1160/TH11-03-0179

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2011; 106(03): 416-422
DOI: 10.1160/TH11-03-0179

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus

Results from the D.E.S.I.R. prospective cohort

Marie-Christine Alessi

¹U626, Inserm, Marseille, France

²Université de la Méditerranée, Marseille, France

,

Viviane Nicaud

³Inserm UMR_S 937, Université Pierre et Marie Curie (UPMC, Paris 6), Paris, France

,

Ilse Scroyen

¹U626, Inserm, Marseille, France

²Université de la Méditerranée, Marseille, France

,

Celine Lange

⁴Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, Villejuif, France

⁵Université Paris Sud 11, UMRS 1018, Villejuif, France

,

Noemie Saut

¹U626, Inserm, Marseille, France

²Université de la Méditerranée, Marseille, France

,

Frederic Fumeron

⁶U695, Inserm, Xavier Bichat Medical School, Paris, France

⁷Université Paris Diderot – Paris 7, Paris, France

,

Michel Marre

⁶U695, Inserm, Xavier Bichat Medical School, Paris, France

⁷Université Paris Diderot – Paris 7, Paris, France

,

Olivier Lantieri

⁸Regional Institute for Health, Tours, France

,

Benedicte Fontaine-Bisson

³Inserm UMR_S 937, Université Pierre et Marie Curie (UPMC, Paris 6), Paris, France

⁹Faculté des Sciences de la Santé, Université d'Ottawa, Ottawa, Ontario, Canada

,

Iréne Juhan-Vague

¹U626, Inserm, Marseille, France

²Université de la Méditerranée, Marseille, France

,

Beverley Balkau

⁴Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, Villejuif, France

⁵Université Paris Sud 11, UMRS 1018, Villejuif, France

,

David-Alexandre Tregouet

³Inserm UMR_S 937, Université Pierre et Marie Curie (UPMC, Paris 6), Paris, France

,

Pierre-Emmanuel Morange

¹U626, Inserm, Marseille, France

²Université de la Méditerranée, Marseille, France

,

D.E.S.I.R. Study Group

› Author Affiliations

Abstract

Summary

It was the objective of this study to investigate the relation between vitronectin and plasminogen activator inhibitor (PAI)-1 plasma levels with nine-year incidences of the metabolic syndrome (MetS) and of type 2 diabetes mellitus (T2DM). Baseline plasma concentrations of vitronectin and PAI-1 were measured in 627 healthy participants from the prospective D.E.S.I.R. cohort who subsequently developed MetS (n=487) and T2DM (n=182) over a nine-year follow-up (42 presented both) and who were matched with two healthy control subjects each by use of a nested case-control design. Parameters composing the MetS explained about 20% of plasma vitronectin levels. An increase of one standard deviation of vitronectin was associated with increased risks of both the MetS (odds ratio [OR] = 1.21 [1.07 – 1.37], p = 0.003) and T2DM (OR = 1.24 [1.01 – 1.53], p = 0.045). Corresponding ORs for PAI-1 levels were 1.46 [1.27 – 1.68] (p < 10⁻⁴) and 1.40 [1.14 – 1.72] (p = 0.0012). However, the effects of vitronectin and PAI-1 levels on outcomes were not independent. The vitronectin–MetS association was restricted to individuals with low to modest PAI-1 levels (OR = 1.33 [1.14 – 1.54], p = 0.0003) while no association was observed in individuals with high PAI-1 levels (OR = 0.87 [0.68 – 1.10], p = 0.24), the test for interaction being highly significant (p = 0.0009). In conclusion, baseline plasma vitronectin is a marker of incident MetS at nine years. Its predictive ability for MetS and T2DM should not be assessed independently of PAI-1 levels.

Keywords

PAI-1 - vitronectin - metabolic syndrome - diabetes

Full Text

References

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