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Thromb Haemost 2011; 106(05): 763-771
DOI: 10.1160/TH11-05-0320
Theme Issue Article
Schattauer GmbH

Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation

Ine M. J. Wolfs
1   Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
,
Marjo M. P. C. Donners
1   Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
,
Menno P. J. de Winther
1   Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
› Author Affiliations Financial support: The work in the group of Dr. de Winther is funded by the Netherlands Heart Foundation (grants 2007T067 and 2010B022) and the Netherlands Organization for Scientific Research (Vidi 016–066–329). Dr. Donners is also supported by the Netherlands Heart Foundation (grant 2007T034). Dr de Winther is an established investigator of the Netherlands Heart Foundation.
Further Information

Publication History

Received: 11 May 2011

Accepted after minor revision: 23 August 2011

Publication Date:
23 November 2017 (online)

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Summary

The phenotype of macrophages in atherosclerotic lesions can vary dramatically, from a large lipid laden foam cell to a small inflammatory cell. Classically, the concept of macrophage heterogeneity discriminates between two extremes called either pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. Polarisation of plaque macrophages is predominantly determined by the local micro-environment present in the atherosclerotic lesion and is rather more complex than typically described by the M1/M2 paradigm. In this review we will discuss the role of various polarising factors in regulating the phenotypical state of plaque macrophages. We will focus on two main levels of phenotype regulation, one determined by differentiation factors produced in the lesion and the other determined by T-cell-derived polarising cytokines. With foam cell formation being a key characteristic of macrophages during atherosclerosis initiation and progression, these polarisation factors will also be linked to lipid handling of macrophages.

Keywords

Macrophage heterogeneity - polarisation - atherosclerosis - cytokines - micro-environment
 

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