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Thromb Haemost 2011; 106(03): 563-565
DOI: 10.1160/TH11-05-0339
DOI: 10.1160/TH11-05-0339
Letters to the Editor
Haplotypes of VKORC1, NQO1 and GGCX, their effect on activity levels of vitamin K-dependent coagulation factors, and the risk of venous thrombosis
Financial support: This study was financially supported by the Netherlands Heart Foundation (NHF grant 2005T55: Dr E. Dekker fellowship to MdV). The LETS study was originally supported by NHF grant 89.063.Weitere Informationen
Publikationsverlauf
Received: 19. Mai 2011
Accepted after major revision: 20. Juni 2011
Publikationsdatum:
24. November 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/201103/lookinside/thumbnails/10-1160-th11-05-0339-1.jpg)
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References
- 1 Rieder MJ, Reiner AP, Gage BF. et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med 2005; 352: 2285-2293.
- 2 Nossent AY, Eikenboom JCJ, Bertina RM. Plasma coagulation factor levels in venous thrombosis. Semin Hematol 2007; 44: 77-84.
- 3 van Hylckama Vlieg A, Callas PW, Cushman M. et al. Inter-relation of coagulation factors and d-dimer levels in healthy individuals. J Thromb Haemost 2003; 1: 516-522.
- 4 Hindorff LA, Heckbert SR, Smith N. et al. Common VKORC1 variants are not associated with arterial or venous thrombosis. J Thromb Haemost 2007; 5: 2025-2027.
- 5 Lacut K, Larramendy-Gozalo C, Le Gal G. et al. Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study. J Thromb Haemost 2007; 5: 2020-2024.
- 6 Smadja DM, Loriot MA, Hindorff LA. et al. No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease. Thromb Haemost 2008; 99: 970-972.
- 7 Verstuyft C, Canonico M, Bouaziz E. et al. VKORC1 genetic polymorphism and risk of venous thromboembolism in postmenopausal women: new findings and meta-analysis. J Thromb Haemost 2009; 7: 1034-1036.
- 8 Watzka M, Westhofen P, Hass M. et al. Polymorphisms in VKORC1 and GGCX are not major genetic determinants of vitamin K-dependent coagulation factor activity in Western Germans. Thromb Haemost 2009; 102: 418-420.
- 9 Buil A, Soria JM, Souto JC. et al. Protein C levels are regulated by a quantitative trait locus on chromosome 16: results from the Genetic Analysis of Idiopathic Thrombophilia (GAIT) Project. Arterioscler Thromb Vasc Biol 2004; 24: 1321-1325.
- 10 Van der Meer FJM, Koster T, Vandenbroucke JP. et al. The Leiden thrombophilia study (LETS). Thromb Haemost 1997; 78: 631-635.
- 11 Poort SR, Rosendaal FR, Reitsma PH. et al. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-3703.
- 12 Koster T, Rosendaal FR, Reitsma PH. et al. Factor VII and fibrinogen levels as risk factors for venous thrombosis: a case control study of plasma levels and DNA polymorphisms – Leiden Thrombophilia Study (LETS). Thromb Haemost 1994; 71: 719-722.
- 13 Koster T, Rosendaal FR, Briët E. et al. Protein C deficiency in a controlled series of unselected outpatients: An infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study). Blood 1995; 85: 2756-2761.
- 14 Geisen C, Watzka M, Sittinger K. et al. VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation. Thromb Haemost 2005; 94: 773-779.
- 15 Purcell S, Neale B, Todd-Brown K. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Gen 2007; 81: 559-575.
- 16 Siegel D, McGuinness SM, Winski SL. et al. Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1. Pharmacogenetics 1999; 9: 113-121.