Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2011; 106(03): 554-555DOI: 10.1160/TH11-06-0437 Letters to the Editor Schattauer GmbH Rebuttal to the letter by J. Höckner: ‘Megakaryocyte gene targeting mediated by restricted expression of recombinase Cre’ Authors Author Affiliations Roberto Parrilla 1 Centro de Investigaciones Biologicas (CSIC), Madrid, Spain Recommend Article Abstract Buy Article(opens in new window) Full Text References References 1 Tropel P, Roullot V, Vernet M. et al. A 2.7-kb portion of the 5’ flanking region of the murine glycoprotein alphaIIb gene is transcriptionally active in primitive hematopoietic progenitor cells. Blood 1997; 90: 2995-3004. 2 Corbel C, Salaün J. αIIb integrin expression during development of the murine hemopoietic system. Dev Biol 2002; 243: 301-311. 3 Ferkowicz MJ, Starr M, Xie X. et al. CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development 2003; 130: 4393-4403. 4 Höckner J. Megakaryocyte-restricted expression of the Cre recombinase. Thromb Haemost 2011; 106: 554. 5 Nowakowski A, Alonso-Martin S, Arias-Salgado EG. et al. Megakaryocyte gene targeting mediated by restricted expression of recombinase Cre. Thromb Haemost 2011; 105: 138-144. 6 Dzierzak E, Speck NA. Of lineage and legacy – the development of mammalian hematopoietic stem cells. Nat Immunol 2008; 9: 129-136. 7 Mikkola HK, Fujiwara Y, Schlaeger TM. et al. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 2003; 101: 508-516. 8 Emambokus NR, Frampton J. The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity 2003; 19: 33-45. 9 Phillips DR, Charo IF, Parise LV. et al. The platelet membrane glycoprotein IIb-IIIa complex. Blood 1988; 71: 831-843. 10 Vinci G, Tabilio A, Deschamps J-F. et al. Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol 1984; 56: 589-605. 11 Nurden AT. Glanzmann thrombasthenia. Orphanet J Rare Dis 2006; 1: 10.
