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Thromb Haemost 2012; 107(02): 270-279
DOI: 10.1160/TH11-07-0463
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Evaluation of the duration of thromboembolic prophylaxis after high-risk orthopaedic surgery: The ETHOS observational study

David Bergqvist
1   Department of Surgery, Uppsala Academic Hospital, Uppsala, Sweden
,
Juan I. Arcelus
2   Department of Surgery, Hospital Virgen de las Nieves, University of Granada, Granada, Spain
,
Paulo Felicissimo
3   Department of Orthopaedic Surgery, Hospital Fernando Fonseca, Amadora, Portugal
,
ETHOS Investigators › Author Affiliations Financial support: The ETHOS study was sponsored by sanofi-aventis (Paris, France).
Further Information

Publication History

Received: 07 July 2011

Accepted after major revision: 28 October 2011

Publication Date:
29 November 2017 (online)

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Summary

Real-life data on post-discharge venous thromboembolism (VTE) prophylaxis practices and treatments are lacking. We assessed post-operative VTE prophylaxis prescribed and received in a prospective registry, compared with the 2004 American College of Chest Physicians (ACCP) guidelines in high-risk orthopaedic surgery patients. Consecutive patients undergoing total hip arthroplasty (THA), hip fracture surgery (HFS), or knee arthroplasty (KA) were enrolled at discharge from 161 centres in 17 European countries if they had received in-hospital VTE prophylaxis that was considered in accordance with the ACCP guidelines by the treating physician. Data on prescribed and actual prophylaxis were obtained from hospital charts and patient post-discharge diaries. Post-operative prophylaxis prescribed and actual prophylaxis received were considered adherent or adequate, respectively, if recommended therapies were used for ≥28 days (HFS and THA) or ≥10 days (KA). Among 4,388 patients, 69.9% were prescribed ACCP-adherent VTE prophylaxis (THA: 1,411/2,217 [63.6%]; HFS: 701/1,112 [63.0%]; KA: 955/1,059 [90.2%]). Actual prophylaxis received was described in 3,939 patients with an available diary after discharge (non-evaluability rate of 10%). Mean actual durations of pharmacological prophylaxis from surgery were: 28.4 ± 13.7 (THA), 29.3 ± 13.9 (HFS), and 28.7 ± 14.1 days (KA). ACCP-adequate VTE prophylaxis was received by 66.5% of patients (60.9% THA, 55.4% HFS, and 88.7% KA). Prophylaxis inadequacies were mainly due to inadequate prescription, non-recommended prophylaxis prescription at discharge, or too short prophylaxis prescribed. In high-risk orthopaedic surgery patients with hospital-initiated prophylaxis, there is a gap between ACCP recommendations, prescribed and actual prophylaxis received, mainly due to inadequate prescription at discharge.

Keywords

Hip fracture surgery - knee arthroplasty - prophylaxis - total hip arthroplasty - venous thromboembolism

* Listed in Appendix.


 

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