Thromb Haemost 2011; 106(06): 1095-1102
DOI: 10.1160/TH11-07-0469
Blood Coagulation, Fibrinolysis, and Cellular Haemostasis
Schattauer GmbH

Venous thromboembolism in patients with symptomatic atherosclerosis

Gregory Piazza
1   Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
,
Samuel Z. Goldhaber
1   Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
,
Darleen M. Lessard
2   Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA
,
Robert J. Goldberg
2   Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA
,
Catherine Emery
2   Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA
,
Frederick A. Spencer
3   Department of Medicine, McMaster University, Hamilton, Ontario, Canada
› Institutsangaben

Financial support: This study was supported by grant R01-HL70283 (PI: Spencer) from the National Heart, Lung, and Blood Institute. Dr. Piazza is supported by a Research Career Development Award (K12 HL083786) from the National Heart, Lung, and Blood Institute (NHLBI). Dr. Spencer is supported by a Career Investigator Award from the Ontario Heart and Stroke Association.
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Publikationsverlauf

Received: 08. Juli 2011

Accepted after major revision: 23. September 2011

Publikationsdatum:
27. November 2017 (online)

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Summary

Patients with atherosclerosis have an increased risk of venous thromboembolism (VTE). We studied patients in the population-based Worcester VTE Study of 1,822 consecutive patients with validated VTE to compare clinical characteristics, prophylaxis, treatment, and outcomes of VTE in patients with and without symptomatic atherosclerotic cardiovascular disease, defined as history of ischaemic heart disease, history of positive cardiac catheterisation, percutaneous coronary intervention, or coronary artery bypass graft surgery, or history of peripheral artery disease. Of the 1,818 patients with VTE, 473 (26%) had a history of symptomatic atherosclerosis. Patients with atherosclerosis were significantly older (mean age 71.9 years vs. 61.6 years) and were more likely to have immobility (57.2% vs. 46.7%), prior heart failure (36.9% vs. 10.7%), chronic lung disease (26.4% vs. 15.5%), cerebrovascular disease (18.1% vs. 9.8%), and chronic kidney disease (4.9% vs. 1.9%) (all p<0.001) compared with non-atherosclerosis patients. Thromboprophylaxis was omitted in more than one-third of atherosclerosis patients who had been hospitalised for non-VTE-related illness or had undergone major surgery within the three months prior to VTE. Patients with atherosclerosis were significantly more likely to suffer in-hospital major bleeding (7.6% vs. 3.8%, p=0.0008). In conclusion, patients with atherosclerosis and VTE are more likely to suffer a complicated hospital course. Despite a high frequency of comorbid conditions contributing to the risk of VTE, we observed a low rate of thromboprophylaxis in patients with symptomatic atherosclerosis.