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Thromb Haemost 2011; 106(05): 757-762
DOI: 10.1160/TH11-07-0500
Theme Issue Article
Schattauer GmbH

Differential role of monocyte subsets in atherosclerosis

Mihail Hristov
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany
,
Christian Weber
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany
2   Munich Heart Alliance, Munich, Germany
› Author Affiliations
Further Information

Publication History

Received: 20 July 2011

Accepted after major revision: 30 August 2011

Publication Date:
23 November 2017 (online)

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Summary

Endothelial dysfunction and inflammation of the arterial wall continuously drive the development of atherosclerosis. Details regarding the sequential involvement of different monocyte subsets in the pathology of this disease have recently emerged. This review concentrates on major monocyte subpopulations in mouse and men and specifically addresses their phenotype, function and recruitment during primary atherosclerosis as well as their contribution to angiogenesis and tissue regeneration secondary to plaque rupture.

Keywords

Atherosclerosis - chemokines - monocytes
 

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