Presence of luminal neutrophil extracellular traps in atherosclerosis

Thromb Haemost 2012; 107(03): 597-598
DOI: 10.1160/TH11-09-0650

Letters to the Editor

Schattauer GmbH

Remco T. A. Megens^*

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany

²Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

,

Santosh Vijayan^*

²Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

,

Dirk Lievens

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany

,

Yvonne Döring

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany

,

Marc A. M. J. van Zandvoort

²Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

³Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, the Netherlands

,

Jochen Grommes

²Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

⁴Department of Vascular Surgery (J.G.), RWTH Aachen University, Aachen, Germany

,

Christian Weber

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany

²Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

³Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, the Netherlands

,

Oliver Soehnlein

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany

²Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany

³Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, the Netherlands

Note: The editorial process for this article was fully handled by Prof. G. Y. H. Lip, Editor-in-Chief.

References
1 Drechsler M, Megens RT, van Zandvoort M. et al. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation 2010; 122: 1837-1845.
2 Brinkmann V, Reichard U, Goosmann C. et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303: 1532-1535.
3 Lande R, Ganguly D, Facchinetti V. et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med. 2011 03. 73ra19.
4 Cros J, Cagnard N, Woollard K. et al. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 2010; 33: 375-386.
5 Fuchs TA, Brill A, Duerschmied D. et al. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA 2010; 107: 15880-15885.
6 Massberg S, Grahl L, von Bruehl ML. et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 2010; 16: 887-896.
7 Ruf W, Ruggeri ZM. Neutrophils release brakes of coagulation. Nat Med 2010; 16: 851-852.
8 Oehmcke S, Mörgelin M, Herwald H. Activation of the human contact system on neutrophil extracellular traps. J Innate Immun 2009; 01: 225-230.
9 Drechsler M, Döring Y, Megens RTA. et al. Neutrophilic granulocytes – promiscuous accelerators of atherosclerosis. Thromb Haemost 2011; 106: 839-848.