Prothrombin complex concentrate-related thrombotic risk following anticoagulation reversal

Thromb Haemost 2012; 107(03): 599
DOI: 10.1160/TH11-11-0773

Author Correspondence

Schattauer GmbH

Peter Toth

¹Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

,

Mike Makris

¹Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK

²Department of Cardiovascular Science, University of Sheffield, Sheffield, UK

References
1 Dentali F, Marchesi C, Pierfranceschi MG. et al. Safety of prothrombin complex concentrates for rapid anti-coagulation reversal of vitamin k antagonists. A meta-analysis. Thromb Haemost 2011; 106: 429-438.
2 Preston FE, Laidlaw ST, Sampson B. et al. Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients. Br J Haematol 2002; 116: 619-624.
3 Carvalho M, Carneiro J, Monteiro C. al. E. Prothrombin complex concentrate for reversal of oral anticoagulation therapy in urgent situations. Experience of a single centre. J Thromb Haemost. 2007 05. (Suppl 2): Abstract P-M-174