Rapid onset heparin-induced thrombocytopenia (HIT) without history of heparin exposure: A new case of so-called ‘spontaneous’ HIT

Thromb Haemost 2012; 107(04): 795-797
DOI: 10.1160/TH11-12-0825

Letters to the Editor

Schattauer GmbH

Julien Perrin

¹Service d'hématologie biologique, Pôle Laboratoires, CHU Nancy, Nancy, France

,

Damien Barraud

²Service de réanimation médicale, Pôle Urgences Réanimation Médicale, CHU Nancy, Nancy, France

,

Marie Toussaint-Hacquard

¹Service d'hématologie biologique, Pôle Laboratoires, CHU Nancy, Nancy, France

,

Pierre-Edouard Bollaert

²Service de réanimation médicale, Pôle Urgences Réanimation Médicale, CHU Nancy, Nancy, France

,

Thomas Lecompte

¹Service d'hématologie biologique, Pôle Laboratoires, CHU Nancy, Nancy, France

References
1 Warkentin TE, Greinacher A, Koster A. et al. American College of Chest Physicians. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 340S-380S.
2 Warkentin TE, Makris M, Jay RM. et al. A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia. Am J Med 2008; 121: 632-636.
3 Jay RM, Warkentin TE. Fatal heparin-induced thrombocytopenia (HIT) during warfarin throm-boprophylaxis following orthopedic surgery: another example of 'spontaneous' HIT?. J Thromb Haemost 2008; 06: 1598-1600.
4 Pruthi RK, Daniels PR, Nambudiri GS. et al. Heparin-induced thrombocytopenia (HIT) during postoperative warfarin thromboprophylaxis: a second example of postorthopedic surgery 'spontaneous' HIT. J Thromb Haemost 2009; 07: 499-501.
5 Krauel K, Pötschke C, Weber C. et al. Platelet factor 4 binds to bacteria, inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia. Blood 2011; 117: 1370-1378.