Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch Famine Birth Cohort: A possible survival advantage?

Federico Lussana; Susanne R. de Rooij; Marjolein Veenendaal; Cristina Razzari; Gessica Fontana; Elena M. Faioni; Rebecca C. Painter; Saskia Middeldorp; Marco Cattaneo; Tessa J. Roseboom

doi:10.1160/TH12-03-0145

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2012; 108(02): 399-401
DOI: 10.1160/TH12-03-0145

Letters to the Editor

Schattauer GmbH

Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch Famine Birth Cohort: A possible survival advantage?

Federico Lussana

¹Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy

,

Susanne R. de Rooij

²Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands

,

Marjolein Veenendaal

²Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands

,

Cristina Razzari

¹Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy

,

Gessica Fontana

¹Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy

,

Elena M. Faioni

¹Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy

,

Rebecca C. Painter

³Department of Gynaecology and Obstetrics, Amsterdam Medical Center, University of Amsterdam, The Netherlands

,

Saskia Middeldorp

⁴Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

,

Marco Cattaneo

¹Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy

,

Tessa J. Roseboom

²Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands

³Department of Gynaecology and Obstetrics, Amsterdam Medical Center, University of Amsterdam, The Netherlands

› Author Affiliations

Abstract

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References

References
1 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134.
2 Rosendaal FR, Doggen CJ, Zivelin A. et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-708.
3 Martinelli I. Risk factors in venous thromboembolism. Thromb Haemost 2001; 86: 395-403.
4 Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001; 344: 1222-1231.
5 Poort SR, Rosendaal FR, Reitsma PH. et al. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-3703.
6 Bertina RM, Koeleman B P, Koster T. et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67.
7 Robertson L, Wu O, Langhorne P. et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006; 132: 171-196.
8 Lindqvist PG, Svensson PJ, Dahlback B. et al. Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism. Thromb Haemost 1998; 79: 69-73.
9 Kerlin BA, Yan SB, Isermann BH. et al. Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Blood 2003; 102: 3085-3092.
10 van Dunne FM, de Craen AJ, Heijmans BT. et al. Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study. Hum Reprod 2006; 21: 967-971.
11 Cohn DM, Repping S, Buller HR. et al. Increased sperm count may account for high population frequency of Factor V Leiden. J Thromb Haemost 2010; 08: 513-516.
12 Gopel W, Ludwig M, Junge AK. et al. Selection pressure for the factor-V-Leiden mutation and embryo implantation. Lancet 2001; 358: 1238-1239.
13 van Mens TE, Kaandorp S P, Goddijn M. et al. Women with factor V Leiden mutation and unexplained recurrent miscarriage have a shorter time to pregnancy than non-carriers; an evolutionary advantage?. Abstracts of the XXIII Congress of the International Society on Thrombosis and Haemostasis OTH 093 J Thromb Haemost. 2011 suppl 2 753.
14 Stein Z, Susser M, Saenger G. et al. Famine and Human Development. The Dutch Hunger Winter of 1944-45. New York: Oxford University Press; 1975
15 Roseboom TJ, van der Meulen JH, Osmond C. et al. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr 2000; 72: 1101-1106.
16 Poort SR, Bertina RM, Vos HL. Rapid detection of the prothrombin 20210 A variation by allele specific PCR. Thromb Haemost 1997; 78: 1157-1158.
17 de Ronde H, Bertina RM. Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria. Thromb Haemost 1994; 72: 880-886.
18 Roseboom TJ, van der Meulen JH, Osmond C. et al. Adult survival after prenatal exposure to the Dutch famine 1944-45. Paediatr Perinat Epidemiol 2001; 15: 220-225.
19 Benfield TL, Dahl M, Nordestgaard BG. et al. Influence of the factor V Leiden mutation on infectious disease susceptibility and outcome: a population-based study. J Infect Dis 2005; 192: 1851-1857.