Management consensus guidance for the use of rivaroxaban – an oral, direct factor Xa inhibitor

Alexander G. G. Turpie; Reinhold Kreutz; Juan Llau; Bo Norrving; Sylvia Haas

doi:10.1160/TH12-03-0209

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2012; 108(05): 876-886
DOI: 10.1160/TH12-03-0209

Consensus Paper

Schattauer GmbH

Management consensus guidance for the use of rivaroxaban – an oral, direct factor Xa inhibitor

Alexander G. G. Turpie

¹Department of Medicine, McMaster University, Hamilton, Ontario, Canada

,

Reinhold Kreutz

²Institute of Clinical Pharmacology and Toxicology, Charité, Universitätsmedizin, Berlin, Germany

,

Juan Llau

³Department of Anaesthesiology and Critical Care, Hospital Clínico, Valencia, Spain

,

Bo Norrving

⁴Department of Clinical Neuroscience, Lund University Hospital, Lund, Sweden

,

Sylvia Haas

⁵Institute for Experimental Oncology and Therapy Research, Technical University of Munich, Germany

› Author Affiliations

Abstract

Summary

A number of novel oral anticoagulants that directly target factor Xa or thrombin have been developed in recent years. Rivaroxaban and apixaban (direct factor Xa inhibitors) and dabigatran etexilate (a direct thrombin inhibitor) have shown considerable promise in large-scale, randomised clinical studies for the management of thromboembolic disorders, and have been approved for clinical use in specific indications. Rivaroxaban is licensed for the prevention of venous thromboembolism in patients undergoing elective hip or knee replacement surgery, the treatment of deep-vein thrombosis and prevention of recurrent venous thromboembolism, and for stroke prevention in patients with non-valvular atrial fibrillation. Based on the clinical trial data for rivaroxaban, feedback on its use in clinical practice and the authors’ experience with the use of rivaroxaban, practical guidance for the use of rivaroxaban in special patient populations and specific clinical situations is provided. Although most recommendations are in line with the European summary of product characteristics for the approved indications, additional and, in several areas, different recommendations are given based on review of the literature and the authors’ clinical experience.

Keywords

Anticoagulant - practical management - recommendations - rivaroxaban

Full Text

References

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