The Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas receptor axis: A potential target for treating thrombotic diseases

Rodrigo A. Fraga-Silva; Danielle G. Da Silva; Fabrizio Montecucco; François Mach; Nikolaos Stergiopulos; Rafaela F. da Silva; Robson A. S. Santos

doi:10.1160/TH12-06-0396

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2012; 108(06): 1089-1096
DOI: 10.1160/TH12-06-0396

Review Article

Schattauer GmbH

The Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas receptor axis: A potential target for treating thrombotic diseases

Rodrigo A. Fraga-Silva

¹Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

,

Danielle G. Da Silva

¹Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

,

Fabrizio Montecucco

²Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, Foundation for Medical Researches, Geneva, Switzerland

³First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy

,

François Mach

²Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, Foundation for Medical Researches, Geneva, Switzerland

,

Nikolaos Stergiopulos

¹Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

,

Rafaela F. da Silva

¹Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

⁴National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Biological Science Institute, Federal University of Minas Gerais, Brazil

,

Robson A. S. Santos

⁴National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Biological Science Institute, Federal University of Minas Gerais, Brazil

› Author Affiliations

Abstract

Summary

Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidity and mortality. Remarkable effort has been made to identify new drug targets. There is growing evidence indicating that the recently described counter-regulator axis of the renin-angiotensin system (RAS), composed of Angiotensin-Converting Enzyme 2 (ACE2), Angiotensin-(1–7) and the Mas receptor, has protective effects against thrombosis. In addition, it could be considered as a promising target for treating or preventing this disease. In this narrative review, we focused on the recent findings of the role of the ACE2/Angiotensin-(1–7)/Mas axis on the haemostatic process and its therapeutic potential.

Keywords

Angiotensin-(1–7) - Angiotensin Converting Enzyme 2 - Receptor Mas - thrombosis - platelet

Full Text

References

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