Parenteral anticoagulants in heart disease: Current status and perspectives (Section II)

Raffaele De Caterina; Steen Husted; Lars Wallentin; Felicita Andreotti; Harald Arnesen; Fedor Bachmann; Colin Baigent; Kurt Huber; Jørgen Jespersen; Steen Dalby Kristensen; Gregory Y. H. Lip; João Morais; Lars Hvilsted Rasmussen; Agneta Siegbahn; Freek W. A. Verheugt; Jeffrey I. Weitz

doi:10.1160/TH12-06-0403

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2013; 109(05): 769-786
DOI: 10.1160/TH12-06-0403

Position Paper

Schattauer GmbH

Parenteral anticoagulants in heart disease: Current status and perspectives (Section II)

Position Paper of the ESC Working Group on Thrombosis – Task Force on Anticoagulants in Heart Disease

Raffaele De Caterina^*

¹Cardiovascular Division, Ospedale SS. Annunziata, G. d’Annunzio University, Chieti, Italy

,

Steen Husted^*

²Medical-Cardiological Department, Aarhus Sygehus, Aarhus, Denmark

,

Lars Wallentin^*

³Cardiology, Uppsala Clinical Research Centre and Department of Medical Sciences, Uppsala University, Uppsala, Sweden

,

Felicita Andreotti^**

⁴Department of Cardiology, Catholic University, Rome, Italy

,

Harald Arnesen^**

⁵Medical Department, Oslo University Hospital, Ulleval, Norway

,

Fedor Bachmann^**

⁶Department of Medicine, University of Lausanne, Lausanne, Switzerland

,

Colin Baigent^**

⁷Cardiovascular Science, Oxford University, Oxford, UK

,

Kurt Huber^**

⁸3rd Department of Medicine, Wilhelminenspital, Vienna, Austria

,

Jørgen Jespersen^**

⁹Unit for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark

,

Steen Dalby Kristensen^**

¹⁰Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark

,

Gregory Y. H. Lip^**

¹¹Haemostasis Thrombosis & Vascular Biology Unit, Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK

,

João Morais^**

¹²Cardiology, Leiria Hospital, Leiria, Portugal

,

Lars Hvilsted Rasmussen^**

¹³Department of Cardiology, Thrombosis Center Aalborg, Aarhus University Hospital, Aalborg, Denmark

,

Agneta Siegbahn^**

¹⁴Coagulation and Inflammation Science, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

,

Freek W. A. Verheugt^**

¹⁵Cardiology, Medical Centre, Radboud University Nijmegen, Nijmegen, Netherlands

,

Jeffrey I. Weitz^**

¹⁶Thrombosis & Atherosclerosis Research Institute, Hamilton General Hospital, Hamilton, Ontario, Canada

› Institutsangaben

Abstract

Summary

Anticoagulants are a mainstay of cardiovascular therapy, and parenteral anticoagulants have widespread use in cardiology, especially in acute situations. Parenteral anticoagulants include unfractionated heparin, low-molecular-weight heparins, the synthetic pentasaccharides fondaparinux, idraparinux and idrabiotaparinux, and parenteral direct thrombin inhibitors. The several shortcomings of unfractionated heparin and of low-molecular-weight heparins have prompted the development of the other newer agents. Here we review the mechanisms of action, pharmacological properties and side effects of parenteral anticoagulants used in the management of coronary heart disease treated with or without percutaneous coronary interventions, cardioversion for atrial fibrillation, and prosthetic heart valves and valve repair. Using an evidence-based approach, we describe the results of completed clinical trials, highlight ongoing research with currently available agents, and recommend therapeutic options for specific heart diseases.

Keywords

Parenteral anticoagulants - coagulation - heart disease - coronary heart disease - heart failure - atrial fibrillation

Volltext

Referenzen

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