Zinc: An important cofactor in haemostasis and thrombosis

Trang T. Vu; James C. Fredenburgh; Jeffrey I. Weitz

doi:10.1160/TH12-07-0465

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 109(03): 421-430
DOI: 10.1160/TH12-07-0465

Review Article

Schattauer GmbH

Zinc: An important cofactor in haemostasis and thrombosis

Authors

Trang T. Vu

¹Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

²Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada
James C. Fredenburgh

¹Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

³Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Jeffrey I. Weitz

¹Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

²Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada

³Department of Medicine, McMaster University, Hamilton, Ontario, Canada

⁴Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

Abstract

Summary

There is mounting evidence that zinc, the second most abundant transition metal in blood, is an important mediator of haemostasis and thrombosis. Prompted by the observation that zinc deficiency is associated with bleeding and clotting abnormalities, there now is evidence that zinc serves as an effector of coagulation, anticoagulation and fibrinolysis. Zinc binds numerous plasma proteins and modulates their structure and function. Because activated platelets secrete zinc into the local microenvironment, the concentration of zinc increases in the vicinity of a thrombus. Consequently, the role of zinc varies depending on the microenvironment; a feature that endows zinc with the capacity to spatially and temporally regulate haemostasis and thrombosis. This paper reviews the mechanisms by which zinc regulates coagulation, platelet aggregation, anticoagulation and fibrinolysis and outlines how zinc serves as a ubiquitous modulator of haemostasis and thrombosis.

Keywords

Zinc - coagulation - contact system - fibrinolysis - platelets

Full Text

References

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