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Thromb Haemost 2013; 109(03): 399-406
DOI: 10.1160/TH12-09-0703
Theme Issue Article
Schattauer GmbH

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

Jindrich Chmelar   *
1   Division on Vascular Inflammation, Diabetes and Kidney, Department of Medicine, University Clinic Carl-Gustav-Carus, Technical University Dresden, Dresden, Germany
2   Institute of Parasitology, Biology Centre, ASCR, Ceske Budejovice, Czech Republic
,
Kyoung-Jin Chung   *
1   Division on Vascular Inflammation, Diabetes and Kidney, Department of Medicine, University Clinic Carl-Gustav-Carus, Technical University Dresden, Dresden, Germany
,
Triantafyllos Chavakis
1   Division on Vascular Inflammation, Diabetes and Kidney, Department of Medicine, University Clinic Carl-Gustav-Carus, Technical University Dresden, Dresden, Germany
› Author Affiliations Financial support:This study was supported by grants from the Else-Kröner-Fresenius Stiftung and the Deutsche Forschungsgemeinschaft.
Further Information

Publication History

Received: 27 September 2012

Accepted after minor revision: 15 January 2012

Publication Date:
29 November 2017 (online)

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Summary

Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development of insulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in AT inflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders.

Keywords

Obesity - adipose tissue - inflammation - review - leukocytes

* These authors contributed equally to this work.


 

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