Evidence on the pathogenic role of auto-antibodies in acute cardiovascular diseases

Federico Carbone; Alessio Nencioni; François Mach; Nicolas Vuilleumier; Fabrizio Montecucco

doi:10.1160/TH12-10-0768

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2013; 109(05): 854-868
DOI: 10.1160/TH12-10-0768

Review Article

Schattauer GmbH

Evidence on the pathogenic role of auto-antibodies in acute cardiovascular diseases

Federico Carbone

¹Department of Internal Medicine, University of Genoa, Genoa, Italy

,

Alessio Nencioni

¹Department of Internal Medicine, University of Genoa, Genoa, Italy

,

François Mach

²Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, Geneva University Hospital, Geneva, Switzerland

,

Nicolas Vuilleumier^*

³Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Switzerland

⁴Department of Human Protein Science, Geneva Faculty of Medicine, Geneva, Switzerland

,

Fabrizio Montecucco^*

¹Department of Internal Medicine, University of Genoa, Genoa, Italy

²Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, Geneva University Hospital, Geneva, Switzerland

› Institutsangaben

Abstract

Summary

Atherothrombosis is the major determinant of acute ischaemic cardiovascular events, such as myocardial infarction and stroke. Inflammatory processes have been linked to all phases of atherogenesis In particular, the identification of autoimmunity mediators in the complex microenvironment of chronic inflammation has become the focus of attention in both early and advanced atherogenic processes. Autoantibodies against self-molecules or new epitopes generated by oxidative processes infiltrate atherosclerotic plaques and were shown to modulate the activity of immune cells by binding various types of receptors. However, despite mounting evidence for a pathophysiological role of autoantibodies in atherothrombosis, the clinical relevance for circulating autoantibodies in cardiovascular outcomes is still debated. This review aims at illustrating the mechanisms by which different types of autoantibodies might either promote or repress atherothrombosis and to discuss the clinical studies assessing the role of auto-antibodies as prognostic biomarkers of plaque vulnerability.

Keywords

Atherosclerosis - auto-antibodies - inflammation - acute myocardial infarction - stroke

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Referenzen

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