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Thromb Haemost 2012; 108(06): 1023
DOI: 10.1160/TH12-10-0783
DOI: 10.1160/TH12-10-0783
T&H Insights
Factor XIII and alternatively activated macrophages – new targets in aortic valve stenosis
Insight FXIII is also present in diseased valve leaflets and atherosclerotic lesionsFurther Information
Publication History
Received:
30 October 2012
Accepted:
30 October 2012
Publication Date:
29 November 2017 (online)

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References
- 1 Kapusta P, Wypasek E, Natorska J. et al. Factor XIII expression within aortic valves and its plasma activity in patients with aortic stenosis: association with severity of disease. Thromb Haemost 2012; 108: 1172-1179.
- 2 Miller JD, Weiss RM, Heistad DD. Calcific aortic valve stenosis: methods, models, and mechansims. Circ Res 2011; 108: 1392-1412.
- 3 Romanic AM, Arleth AJ, Willette RN. et al. Factor XIIIa cross-links lipoprotein(a) with fibrinogen and is present in human atherosclerotic lesions. Circ Res 1998; 83: 264-269.
- 4 Wolfs IMJ, Donners MMPC, de Winther MPJ. Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation. Thromb Haemost 2011; 106: 763-771.