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Thromb Haemost 2013; 110(04): 669-680
DOI: 10.1160/TH13-01-0075
Theme Issue Article
Schattauer GmbH

Thrombosis in central obesity and metabolic syndrome: Mechanisms and epidemiology

Pierre-Emmanuel Morange
1   Laboratoire d’Hématologie, Inserm UMR 1062, Faculté de Médecine, Université de la Méditerranée, Marseille, France
,
Marie-Christine Alessi
1   Laboratoire d’Hématologie, Inserm UMR 1062, Faculté de Médecine, Université de la Méditerranée, Marseille, France
› Author Affiliations
Further Information

Publication History

Received: 29 January 2013

Accepted after major revision: 20 April 2013

Publication Date:
01 December 2017 (online)

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summary

Central obesity is a key feature of the metabolic syndrome (metS), a multiplex risk factor for subsequent development of type 2 diabetes and cardiovascular disease. Many metabolic alterations closely related to this condition exert effects on platelets and vascular cells. A procoagulant and hypofibrinolytic state has been identified, mainly underlain by inflammation, oxidative stress, dyslipidaemia, and ectopic fat that accompany central obesity. In support of these data, central obesity independently predisposes not only to atherothrombosis but also to venous thrombosis.

Keywords

Haemostasis - metabolic syndrome - visceral obesity - thrombosis
 

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