Crosstalk between platelets and the complement system in immune protection and disease

Admar Verschoor; Harald F. Langer

doi:10.1160/TH13-02-0102

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(05): 910-919
DOI: 10.1160/TH13-02-0102

Theme Issue Article

Schattauer GmbH

Crosstalk between platelets and the complement system in immune protection and disease

Admar Verschoor

¹1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany

,

Harald F. Langer

²Medizinische Klinik III, Klinik für Kardiologie und Kreislauf erkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany

› Author Affiliations

Abstract

Summary

Platelets have a central function in repairing vascular damage and stopping acute blood loss. They are equally central to thrombus formation in cardiovascular diseases such as myocardial infarction and ischaemic stroke. Beyond these classical prothrombotic diseases, immune mediated pathologies such as haemolytic uraemic syndrome (HUS) or paroxysmal nocturnal haemoglobinuria (PNH) also feature an increased tendency to form thrombi in various tissues. It has become increasingly clear that the complement system, part of the innate immune system, has an important role in the pathophysiology of these diseases. Not only does complement influence prothrombotic disease, it is equally involved in idiopathic thrombocytopenic purpura (ITP), an autoimmune disease characterised by thrombocytopenia. Thus, there are complex interrelationships between the haemostatic and immune systems, and platelets and complement in particular. Not only does complement influence platelet diseases such as ITP, HUS and PNH, it also mediates interaction between microbes and platelets during systemic infection, influencing the course of infection and development of protective immunity. This review aims to provide an integrative overview of the mechanisms underlying the interactions between complement and platelets in health and disease.

Keywords

Platelets - complement - inflammation - infectious disease - ITP - HUS - PNH

Full Text

References

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