Plasma kallikrein: the bradykinin-producing enzyme

Jenny Björkqvist; Anne Jämsä; Thomas Renné

doi:10.1160/TH13-03-0258

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(03): 399-407
DOI: 10.1160/TH13-03-0258

Theme Issue Article

Schattauer GmbH

Plasma kallikrein: the bradykinin-producing enzyme

Jenny Björkqvist

¹Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

²Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

,

Anne Jämsä

¹Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

²Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

,

Thomas Renné

¹Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

²Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

³Institute of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, Germany

› Author Affiliations

Abstract

Summary

Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway. Here, we review the biochemistry and cell biology of PK and focus on recent in vivo studies that have established important functions of the protease in procoagulant and proinflammatory disease states. Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases.

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References

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