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Thromb Haemost 2013; 110(05): 894-902
DOI: 10.1160/TH13-04-0341
Theme Issue Article
Schattauer GmbH

Platelet chemokines in health and disease

Ela Karshovska
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians University (LMU) Munich, Germany
,
Christian Weber
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians University (LMU) Munich, Germany
,
Philipp von Hundelshausen
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians University (LMU) Munich, Germany
› Author Affiliations
Further Information

Publication History

Received: 25 April 2013

Accepted after major revision: 17 May 2013

Publication Date:
01 December 2017 (online)

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Summary

In recent years, it has become clear that platelets and platelet-derived chemokines, beyond their role in thrombosis and haemostasis, are important mediators affecting a broad spectrum of (patho)physiological conditions. These biologically active proteins are released from α-granules upon platelet activation, most probably even during physiological conditions. In this review, we give a concise overview and an update on the current understanding of platelet-derived chemokines in a context of health and disease.

Note: The review process for this manuscript was fully handled by G. Y. H. Lip, Editor in Chief.

Keywords

Platelet immunology - chemokines - atherosclerosis - inflammation - infectious diseases
 

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