Thromb Haemost 2014; 111(06): 1197-1199
DOI: 10.1160/TH13-11-0963
Letters to the Editor
Schattauer GmbH

Long-term strenuous exercise induces a hypercoagulable state through contact activation

Jelle J. Posthuma
1   Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands
,
Rinske Loeffen
1   Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands
,
René van Oerle
1   Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands
2   Haemostasis Laboratory, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands
,
Yvonne M. C. Henskens
2   Haemostasis Laboratory, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands
,
Hugo ten Cate
1   Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands
,
Henri M. H. Spronk
1   Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands
,
Paola E. J. van der Meijden
1   Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands
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Weitere Informationen

Publikationsverlauf

Received: 21. November 2013

Accepted after minor revision: 28. Januar 2013

Publikationsdatum:
21. November 2017 (online)

 

 
  • References

  • 1 Lippi G, Maffulli N. Biological influence of physical exercise on hemostasis. Semin Thromb Hemost 2009; 35: 269-276.
  • 2 Siscovick DS, Weiss NS, Fletcher RH. et al. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med 1984; 311: 874-877.
  • 3 Loeffen R, Kleinegris MC, Loubele ST. et al. Preanalytical variables of thrombin generation: towards a standard procedure and validation method. J Thromb Haemost 2012; 10: 2544-2554.
  • 4 Steensberg A, Van Hall G, Osada T. et al. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 2000; 529: 237-242.
  • 5 Steensberg A, Toft A, Schjerling P. et al. Plasma interleuking-6 during strenuous exercise: role of epinephrine. Am J Physiol Cell Physiol 2001; 281: C1001-C1004.
  • 6 Bethin KE, Vogt SK, Muglia LJ. Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation. Proc Natl Acad Sci USA 2000; 97: 9317-9322.
  • 7 Chamberlain KG, Tong M, Penington DG. Properties of the exchangeable splenic platelets released into the circulation during exercise-induced thrombocytosis. Am J Hematol 1990; 34: 161-168.
  • 8 Röcker L, Drygas WK, Heyduck B. Blood platelet activation and increase in thrombin activity following a marathon race. Eur J Appl Physiol Occup Physiol 1986; 55: 374-380.
  • 9 Sumann G, Fries D, Griesmacher A. et al. Blood coagulation activation and fibrinolysis during a downhill marathon run. Blood Coagul Fibrinolysis 2007; 18: 435-440.
  • 10 Bärtsch P, Welsch B, Albert M. et al. Balanced activation of coagulation and fibrinolysis after a 2-h triathlon. Med Sci Sports Exerc 1995; 27: 1465-1470.
  • 11 Chen Yw, Chen JK, Wang JS. Strenuous exercise promotes shear-induced thrombin generation by increasing the shedding of procoagulant microparticles from platelets. Thromb Haemost 2010; 104: 293-301.
  • 12 Van der Meijden PE, Van Schilfgaarde M, Van Oerle R. et al. Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa. J Thromb Haemost 2012; 10: 1355-1362.