Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults

Kyla M. Shea; Mary Cushman; Sarah L. Booth; Gregory L. Burke; Haiying Chen; Stephen B. Kritchevsky

doi:10.1160/TH13-12-1003

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2014; 112(03): 438-444
DOI: 10.1160/TH13-12-1003

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults

The Multi-Ethnic Study of Atherosclerosis

Kyla M. Shea

¹USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA

,

Mary Cushman

²Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA

,

Sarah L. Booth

¹USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA

,

Gregory L. Burke

³Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

,

Haiying Chen

³Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

,

Stephen B. Kritchevsky

⁴Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem North Carolina, USA

› Author Affiliations

Abstract

Summary

Vitamin K is integral to haemostatic function, and in vitro and animal experiments suggest that vitamin K can suppress production of inflammatory cytokines. To test the hypothesis that higher vitamin K status is associated with lower haemostatic activation and inflammation in community-dwelling adults, we analysed the cross-sectional association between serum phylloquinone (vitamin K1) with haemostatic and inflammatory biomarkers in 662 participants in the Multi- Ethnic Study of Atherosclerosis (MESA) [mean (SD) age=62 (10) years; 46% female; 37% Caucasian, 25% African-American, 25% Hispanic, 13% Chinese-American]. Following adjustment for demographic and lifestyle characteristics, medication use, triglycerides and body mass index, those in the highest quartile of serum phylloquinone had significantly lower circulating interleukin-6 [adjusted mean (SEM) pmol/l: quartile 4 (Q4)=1.22 (0.07), quartile 1 (Q1)=1.45 (0.07); p-trend<0.01], C-reactive protein [adjusted mean (SEM) mg/dl: Q4=1.57 (0.11), Q1=2.08 (0.18); p-trend=0.02], soluble intercellular adhesion molecule-1 [adjusted mean (SEM) ng/ml: Q4=247 (11), Q1=288 (11); p-trend=0.02], and plasmin-antiplasmin complex [adjusted mean (SEM) nmol/l: Q4=4.02 (0.1), Q1=4.31 (0.1), p-trend=0.04]. We detected an interaction between age and serum phylloquinone with respect to factor VIII and D-dimer (interaction p-values=0.03 and 0.09, respectively). Among participants ≥70 years, serum phylloquinone was inversely associated with factor VIII activity (p-trend=0.06) and positively associated with D-dimer (p-trend=0.01), but was not associated with either marker among participants <70 years (both p≥0.38). In contrast, dietary phylloquinone intake was not associated with any inflammatory or haemostatic biomarker evaluated (all p-trend>0.11). These findings are consistent with laboratorybased studies that suggest a possible anti-inflammatory role for vitamin K. Whether or not these associations predict clinical outcomes linked to elevated inflammation or haemostatic activation remains to be determined.

Keywords

Haemostasis - inflammation - nutrition - epidemiological studies

Full Text

References

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