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Thromb Haemost 2014; 112(03): 438-444
DOI: 10.1160/TH13-12-1003
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults

The Multi-Ethnic Study of Atherosclerosis
Kyla M. Shea
1   USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
,
Mary Cushman
2   Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA
,
Sarah L. Booth
1   USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
,
Gregory L. Burke
3   Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
,
Haiying Chen
3   Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
,
Stephen B. Kritchevsky
4   Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem North Carolina, USA
› Author Affiliations Financial support: This research was supported by contracts N01-HC-95159 through N01-HC-95169 from the National Heart, Lung, and Blood Institute, the National Institute of Aging (P30AG021332–08), the American Heart Association (09CRP2070013), the Wake Forest University Claude D. Pepper Older Americans Independence Center (P30-AG21332), the National Institute of Arthritis and Musculoskeletal Disease (K01AR063167), and the U.S. Department of Agriculture, Agricultural Research Service under Cooperative Agreement No. 58–1950–7–707.
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Publication History

Received: 10 December 2013

Accepted after major revision: 22 March 2014

Publication Date:
20 November 2017 (online)

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Summary

Vitamin K is integral to haemostatic function, and in vitro and animal experiments suggest that vitamin K can suppress production of inflammatory cytokines. To test the hypothesis that higher vitamin K status is associated with lower haemostatic activation and inflammation in community-dwelling adults, we analysed the cross-sectional association between serum phylloquinone (vitamin K1) with haemostatic and inflammatory biomarkers in 662 participants in the Multi- Ethnic Study of Atherosclerosis (MESA) [mean (SD) age=62 (10) years; 46% female; 37% Caucasian, 25% African-American, 25% Hispanic, 13% Chinese-American]. Following adjustment for demographic and lifestyle characteristics, medication use, triglycerides and body mass index, those in the highest quartile of serum phylloquinone had significantly lower circulating interleukin-6 [adjusted mean (SEM) pmol/l: quartile 4 (Q4)=1.22 (0.07), quartile 1 (Q1)=1.45 (0.07); p-trend<0.01], C-reactive protein [adjusted mean (SEM) mg/dl: Q4=1.57 (0.11), Q1=2.08 (0.18); p-trend=0.02], soluble intercellular adhesion molecule-1 [adjusted mean (SEM) ng/ml: Q4=247 (11), Q1=288 (11); p-trend=0.02], and plasmin-antiplasmin complex [adjusted mean (SEM) nmol/l: Q4=4.02 (0.1), Q1=4.31 (0.1), p-trend=0.04]. We detected an interaction between age and serum phylloquinone with respect to factor VIII and D-dimer (interaction p-values=0.03 and 0.09, respectively). Among participants ≥70 years, serum phylloquinone was inversely associated with factor VIII activity (p-trend=0.06) and positively associated with D-dimer (p-trend=0.01), but was not associated with either marker among participants <70 years (both p≥0.38). In contrast, dietary phylloquinone intake was not associated with any inflammatory or haemostatic biomarker evaluated (all p-trend>0.11). These findings are consistent with laboratorybased studies that suggest a possible anti-inflammatory role for vitamin K. Whether or not these associations predict clinical outcomes linked to elevated inflammation or haemostatic activation remains to be determined.

Keywords

Haemostasis - inflammation - nutrition - epidemiological studies

 

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