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Thromb Haemost 2014; 112(01): 32-42
DOI: 10.1160/TH14-01-0032
Review Article
Schattauer GmbH

Fibrin clot properties and their modulation in thrombotic disorders

Anetta Undas
1   Institute of Cardiology, Jagiellonian University School of Medicine, and the John Paul II Hospital, Krakow, Poland
› Author Affiliations
Further Information

Publication History

Received: 13 January 2014

Accepted after minor revision: 19 February 2014

Publication Date:
01 December 2017 (online)

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Summary

Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clot structure and function in patients with various thromboembolic manifestations, in particular myocardial infarction, ischaemic stroke and venous thromboembolism, based on the publications till December 2013. Moreover, factors will be presented that in vivo unfavourably determine altered fibrin clot properties in thrombotic disorders and modalities that can improve clot phenotype.

Keywords

Fibrin clot - fibrinolysis - thrombosis
 

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