Fibrin clot properties and their modulation in thrombotic disorders

Anetta Undas

doi:10.1160/TH14-01-0032

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2014; 112(01): 32-42
DOI: 10.1160/TH14-01-0032

Review Article

Schattauer GmbH

Fibrin clot properties and their modulation in thrombotic disorders

Anetta Undas

¹Institute of Cardiology, Jagiellonian University School of Medicine, and the John Paul II Hospital, Krakow, Poland

› Author Affiliations

Abstract

Summary

Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clot structure and function in patients with various thromboembolic manifestations, in particular myocardial infarction, ischaemic stroke and venous thromboembolism, based on the publications till December 2013. Moreover, factors will be presented that in vivo unfavourably determine altered fibrin clot properties in thrombotic disorders and modalities that can improve clot phenotype.

Keywords

Fibrin clot - fibrinolysis - thrombosis

Full Text

References

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