Association between pneumoconiosis and pulmonary emboli

Chih-Hao Shen; Hsuan-Ju Chen; Te-Yu Lin; Wen-Yen Huang; Tsai-Chung Li; Chia-Hung Kao

doi:10.1160/TH14-10-0858

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2015; 113(05): 952-957
DOI: 10.1160/TH14-10-0858

Coagulation and Fibrinolysis

Schattauer GmbH

Association between pneumoconiosis and pulmonary emboli

A Nationwide Population-Based Study in Taiwan

Chih-Hao Shen

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

,

Hsuan-Ju Chen

²Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

³College of Medicine, China Medical University, Taichung, Taiwan

,

Te-Yu Lin

⁴Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

,

Wen-Yen Huang

⁵Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

,

Tsai-Chung Li

⁶Graduate Institute of Biostatistics, College of Management, China Medical University, Taichung, Taiwan

⁷Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan

,

Chia-Hung Kao

⁸Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

⁹Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

› Author Affiliations

Abstract

Summary

Studies on the association between pneumoconiosis and deep-vein thrombosis (DVT) and pulmonary thromboembolism (PE) are few. This study was based on data obtained from the Taiwan National Health Insurance Database from 2000 to 2006, with a follow-up period extending to the end of 2011. We identified 3719 pneumoconiosis patients and 14876 non-pneumoconiosis patients who were selected by frequency matched based on sex, age, and the index year. We analysed the risks of DVT and PE by using Cox proportional hazards regression models by including sex, age, and CCI score. The risk of developing PE was 1.90-fold in the patients with pneumoconiosis compared with the comparison cohort after adjustments for age, sex, and CCI score. By contrast, we did not observe significant effect of pneumoconiosis on DVT. However, the cumulative incidence curves for DVT were similar in the pneumoconiosis patients and non-pneumoconiosis patients. The multiplicative increased risks of PE were significant in patients with pneumoconiosis and CCI score of one and more. In conclusion, physicians should include pneumoconiosis in evaluating pulmonary embolism risk.

Keywords

National Health Insurance Database - pneumoconiosis - pulmonary embolism - venous thrombosis

Full Text

References

References
1 Fourth International Pneumoconiosis Conference. Report of the Working Party on the Definition of Pneumoconiosis. Geneva, Switzerland: International Labour Organization 1971
2 Fujimura N. Pathology and pathophysiology of pneumoconiosis. Curr Opin Pulm Med 2000; 06: 140-144.
3 Castranova V, Vallyathan V. Silicosis and coal workers’ pneumoconiosis. Environ Health Perspect 2000; 108: 675-684.
4 Cohen RA, Patel A, Green FH. Lung disease caused by exposure to coal mine and silica dust. Semin Respir Crit Care Med 2008; 29: 651-661.
5 Yucesoy B, Vallyathan V, Landsittel DP. et al. Cytokine polymorphisms in silicosis and other pneumoconioses. Mol Cell Biochem 2002; 234-235: 219-224.
6 Heit JA. Venous thromboembolism: disease burden, outcomes and risk factors. J ThrombHaemost 2005; 03: 1611-1617.
7 Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis. Lancet 2012; 379: 1835-1846.
8 Virchow R. Gesammelte Abhandlungen zur wissenschaftlichen Medicin. Frankfurt: Verlag von MeidlingerSohn 1856
9 Kyrle PA, Eichinger S. Deep vein thrombosis. Lancet 2005; 365: 1163-1174.
10 Fox EA, Kahn SR. The relationship between inflammation and venous thrombosis. A systematic review of clinical studies. Thromb Haemost 2005; 94: 362-365.
11 Xu J, Lupu F, Esmon CT. Inflammation, innate immunity and blood coagulation. Hamostaseologie 2010; 30: 5-6-8-9.
12 Zhang C. The role of inflammatory cytokines in endothelial dysfunction. Basic Res Cardiol 2008; 103: 398-406.
13 Zöller B, Li X, Sundquist J. et al. Autoimmune diseases and venous thromboembolism: a review of the literature. Am J Cardiovasc Dis 2012; 02: 171-183.
14 Schneider C, Bothner U, Jick SS. et al. Chronic obstructive pulmonary disease and the risk of cardiovascular diseases. Eur J Epidemiol 2010; 25: 253-260.
15 Bertoletti L, Quenet S, Mismetti P. et al. RIETE Investigators. Clinical presentation and outcome of venous thromboembolism in COPD. Eur Respir J 2012; 39: 862-868.
16 Charlson ME, Pompei P, Ales KL. et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383.
17 White RH. The epidemiology of venous thromboembolism. Circulation 2003; 107: I4-I8.
18 Diebold J, Lohrs U. Venous thrombosis and pulmonary embolism. A study of 5039 autopsies. Pathol Res Pract 1991; 187: 260-266.
19 Velmahos GC, Spaniolas K, Tabbara M. et al. Pulmonary embolism and deep venous thrombosis in trauma: are they related?. Arch Surg 2009; 144: 928-932.
20 Schwartz T, Hingorani A, Ascher E. et al. Pulmonary embolism without deep venous thrombosis. Ann Vasc Surg 2012; 26: 973-976.
21 Van Gent JM, Zander AL, Olson EJ. et al. Pulmonary embolism without deep venous thrombosis: De novo or missed deep venous thrombosis?. J Trauma Acute Care Surg 2014; 76: 1270-1274.
22 Kuppalli K, Livorsi D, Talati NJ. et al. Lemierre’s syndrome due to Fusobacteriumnecrophorum. Lancet Infect Dis 2012; 12: 808-815.
23 Hu SN, Vallyathan V, Green FH. et al. Pulmonary arteriolar muscularization in coal workers’ pneumoconiosis and its correlation with right ventricular hypertrophy. Arch Pathol Lab Med 1990; 114: 1063-1070.
24 Murray J, Reid G, Kielkowski D. et al. Corpulmonale and silicosis: a necropsy based case-control study. Br J Ind Med 1993; 50: 544-548.
25 Lopez JA, Chen J. Pathophysiology of venous thrombosis. Thromb Res 2009; 123: S30-S34.
26 Hamer JD, Malone PC, Silver IA. The PO2 in venous valve pockets: its possible bearing on thrombogenesis. Br J Surg 1981; 68: 166-170.
27 Levi M, van der Poll T, ten Cate H. Tissue factor in infection and severe inflammation. Semin Thromb Hemost 2006; 32: 33-39.
28 Montagnana M, Favaloro EJ, Franchini M, Guidi GC, Lippi G. The role of ethnicity, age and gender in venous thromboembolism. J Thromb Thrombolysis 2010; 29: 489-496.
29 Franchini M, Mannucci PM. ABO blood group and thrombotic vascular disease. Thromb Haemost 2014; 112: 1103-1109.