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Thromb Haemost 2015; 114(04): 859-861
DOI: 10.1160/TH15-01-0040
Letters to the Editor
Schattauer GmbH

A novel mutation of antithrombin deficiency in six family siblings and the clinical combat

Yona Nadir
1   Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus, Haifa, Israel
,
Ron Hoffman
1   Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus, Haifa, Israel
,
Javier Corral
2   Centro Regional de Hemodonación, C/ Ronda de Garay s/n, Murcia, Spain
,
Yaron Barak
3   Department of Cardiac Surgery, Rambam Health Care Campus, Haifa, Israel
,
Tal Hasin
4   Department of Cardiology, Rambam Health Care Campus, Haifa, Israel
,
Anat Keren-Politansky
1   Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus, Haifa, Israel
,
Benjamin Brenner
1   Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus, Haifa, Israel
› Author Affiliations
Further Information

Publication History

Received: 15 January 2015

Accepted after major revision: 16 April 2015

Publication Date:
29 November 2017 (online)

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  • References

  • 1 Kenet G, Lutkhoff LK, Albisetti M. et al. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation 2010; 121: 1838-1847.
    CrossrefPubMedSearch in Google Scholar
  • 2 Calcaterra D, Martin JT, Ferneini AM. et al. Acute mesenteric and aortic thrombosis associated with antithrombin deficiency: a rare occurrence. Ann Vasc Surg 2010; 24: 415e5-7.
    PubMedSearch in Google Scholar
  • 3 Tu CM, Hsueg CH, Chu KM. et al. Simultaneous thromboses of double coronary arteries in a young male with antithrombin III deficiency. Am J Emerg Med 2009; 27: 1169e3-6.
    PubMedSearch in Google Scholar
  • 4 Roldan V, Ordonez A, Marin F. et al. Antithrombin Cambridge II (A384S) supports a role for anti-thrombin deficiency in arterial thrombosis. Thromb Haemost 2009; 101: 483-486.
    Thieme ConnectPubMedSearch in Google Scholar
  • 5 Corral J, Hernandez-Espinosa D, Soria JM. et al. Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis. Blood 2007; 109: 4258-4263.
    CrossrefPubMedSearch in Google Scholar
  • 6 Zeng W, Tang L, Jian XR. et al. Genetic analysis should be included in clinical practice when screening for antithrombin deficiency. Thromb Haemost 2015; 113: 262-271.
    Thieme ConnectPubMedSearch in Google Scholar