Extended anticoagulation with apixaban reduces hospitalisations in patients with venous thromboembolism

Xianchen Liu; John Thompson; Hemant Phatak; Jack Mardekian; Anthony Porcari; Margot Johnson; Alexander T. Cohen

doi:10.1160/TH15-07-0606

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2016; 115(01): 161-168
DOI: 10.1160/TH15-07-0606

Stroke, Systemic or Venous Thromboembolism

Schattauer GmbH Schattauer

Extended anticoagulation with apixaban reduces hospitalisations in patients with venous thromboembolism

An analysis of the AMPLIFY-EXT trial

Authors

Xianchen Liu

¹Pfizer Inc., New York, New York, USA
John Thompson

²Pfizer Inc., Groton, Conneticut, USA
Hemant Phatak

³Bristol-Myers Squibb Inc., Princeton, New Jersey, USA
Jack Mardekian

¹Pfizer Inc., New York, New York, USA
Anthony Porcari

²Pfizer Inc., Groton, Conneticut, USA
Margot Johnson

²Pfizer Inc., Groton, Conneticut, USA
Alexander T. Cohen

⁴Guy’s and St Thomas’ Hospitals, Westminster Bridge Road, London, UK

Abstract

Summary

Treatment with apixaban versus placebo for 12 months significantly reduced symptomatic recurrent venous thromboembolism (VTE) or all-cause death without increasing the rate of major bleeding in the AMPLIFY-EXT trial. This analysis examined the effects of apixaban versus placebo on the rate of all-cause hospitalisations, time to first hospitalisation, and predictors of first hospitalisation in patients with VTE enrolled in AMPLIFY-EXT. Treatment with apixaban 2.5 mg and 5 mg twice daily significantly reduced the rate of all-cause hospitalisations versus placebo (hazard ratio [95 % confidence interval], 0.64 [0.43, 0.95]; p=0.026 and 0.54 [0.36, 0.82]; p=0.004, respectively). Apixaban prolonged mean time to first hospitalisation versus placebo by 43 and 49 days for the 2.5-mg and 5-mg twice-daily groups, respectively. Median length of hospital stay during the first hospitalisation was longer for placebo than for apixaban 2.5 mg or 5 mg twice daily (7.0, 5.0, and 4.5 days, respectively). Treatment with apixaban was a significant predictor of lower rates of hospitalisations versus placebo, and severe/moderate renal impairment was a significant predictor of an increased rate. This study supports extended use of apixaban for reducing all-cause hospitalisations and extending time to first hospitalisation in patients with VTE enrolled in AMPLIFY-EXT (www.clinical trials.gov registration: #NCT00633893).

Keywords

Apixaban - hospitalisation - venous thromboembolism - extended anticoagulation

Full Text

References

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