Download PDF
Thromb Haemost 2016; 116(03): 407
DOI: 10.1160/TH16-07-0574
T&H Insights
Schattauer GmbH

Myeloid IL-10 receptor signalling as pro-atherogenic factor modulating cholesterol homeostasis

François Mach
1   Division of Cardiology, University of Geneva, Geneva, Switzerland
,
Karim J. Brandt
1   Division of Cardiology, University of Geneva, Geneva, Switzerland
› Author Affiliations
Further Information

Publication History

Received: 26 July 2016

Accepted: 26 July 2016

Publication Date:
28 November 2017 (online)

Also available at
    Permissions and Reprints

 

  • References

  • 1 Spitz C, Winkels H, Bürger C. et al. Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential. Cell Mol Life Sci 2016; 73: 901-922.
    CrossrefPubMedSearch in Google Scholar
  • 2 Li J, McArdle S, Gholami A. et al. CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis. Circ Res 2016; 118: 1540-1552.
    CrossrefPubMedSearch in Google Scholar
  • 3 Strom AC, Cross AJ, Cole JE. et al. B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10. Thromb Haemost 2015; 114: 835-847.
    Thieme ConnectPubMedSearch in Google Scholar
  • 4 Halvorsen B, Waehre T, Scholz H. et al. Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms. J Lipid Res 2005; 46: 211-219.
    CrossrefPubMedSearch in Google Scholar
  • 5 Han X, Boisvert WA.. Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function. Thromb Haemost 2015; 113: 505-512.
    Thieme ConnectPubMedSearch in Google Scholar
  • 6 Stöger JL, Boshuizen MC, Brufau G. et al. Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes. Thromb Haemost 2016; 116: 565-577.
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Allavena P, Piemonti L, Longoni D. et al. IL-10 prevents the generation of dendritic cells from CD14+ blood monocytes, promotes the differentiation to mature macrophages and stimulates endocytosis of FITC-dextran. Adv Exp Med Biol 1997; 417: 323-327.
    PubMedSearch in Google Scholar